A new chromogranin A–dependent angiogenic switch activated by thrombin

• Published in: Blood Vol. 121; no. 2; pp. 392 - 402
• Main Authors: Crippa, Luca, Bianco, Mimma, Colombo, Barbara, Gasparri, Anna M., Ferrero, Elisabetta, Loh, Y. Peng, Curnis, Flavio, Corti, Angelo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.01.2013; American Society of Hematology
• Subjects: Animals; Chick Embryo; Chromogranin A - chemistry; Chromogranin A - metabolism; Enzyme-Linked Immunosorbent Assay; Humans; Mice; Neovascularization, Pathologic - metabolism; Neovascularization, Physiologic - physiology; Peptide Fragments - chemistry; Peptide Fragments - metabolism; Rats; Structure-Activity Relationship; Vascular Biology

Angiogenesis, the formation of blood vessels from pre-existing vasculature, is regulated by a complex interplay of anti and proangiogenic factors. We found that physiologic levels of circulating chromogranin A (CgA), a protein secreted by the neuroendocrine system, can inhibit angiogenesis in variou...