Biological effects of rutin on skin aging

• Published in: International journal of molecular medicine Vol. 38; no. 1; pp. 357 - 363
• Main Authors: CHOI, SEONG JIN, LEE, SUNG-NAE, KIM, KARAM, JOO, DA HYE, SHIN, SHANGHUN, LEE, JEONGJU, LEE, HYUN KYUNG, KIM, JIHYUN, KWON, SEUNG BIN, KIM, MIN JUNG, AHN, KYU JOONG, AN, IN-SOOK, AN, SUNGKWAN, CHA, HWA JUN
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.07.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adult; Aging; Antioxidants; Cell culture; Cell Death - drug effects; Cell Survival - drug effects; Cellular Senescence - drug effects; clinical efficacy; Collagen; Collagen Type I - genetics; Collagen Type I - metabolism; Cytotoxicity; Dermis - pathology; Elastic Modulus - drug effects; Elasticity; Experiments; extracellular matrix; Female; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - pathology; human dermal fibroblast; Humans; Hydrogen Peroxide - toxicity; Matrix Metalloproteinase 1 - genetics; Matrix Metalloproteinase 1 - metabolism; Middle Aged; Observations; Production increases; Reactive oxygen species; RNA, Messenger - genetics; RNA, Messenger - metabolism; rutin; Rutin - pharmacology; Senescence; Skin; Skin Aging - drug effects; Skin Cream - pharmacology; United States > US

Rutin, a quercetin glycoside is a member of the bioflavonoid family which is known to possess antioxidant properties. In the present study, we aimed to confirm the anti-aging effects of rutin on human dermal fibroblasts (HDFs) and human skin. We examined the effects of rutin using a cell viability a...