Preconditioning With Ozone Abrogates Acute Rejection and Prolongs Cardiac Allograft Survival in Rats

• Published in: Transplantation proceedings Vol. 40; no. 4; pp. 974 - 977
• Main Authors: Stadlbauer, T.H.W, Eisele, A, Heidt, M.C, Tillmanns, H.H, Schulz, S
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2008; Elsevier Science
• Subjects: Animals; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Rejection - prevention & control; Heart Transplantation - physiology; Immunosuppressive Agents - therapeutic use; Male; Medical sciences; Models, Animal; Ozone - therapeutic use; Rats; Rats, Inbred WF; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Tissue, organ and graft immunology; Transplantation Conditioning - methods; Transplantation, Homologous - physiology; Heart; Graft(material); Prognosis; Rat; Acute; Rodentia; Ozone; Transplantation; Homotransplantation; Survival; Medicine; Rejection; Vertebrata; Mammalia; Treatment; Surgery; Animal; Graft; Circulatory system; Preconditioning; Prolonged

Abstract Acute cardiac allograft rejection remains a major cause of morbidity and mortality after heart transplantation and predisposes for the development of graft vasculopathy. The aim of this study was to investigate the immunomodulatory effect of preconditioning of the donor and recipient with m...