Comparative Histopathologic Lesions of the Male Reproductive Tract during Acute Infection of Zika Virus in AG129 and Ifnar−/− Mice

• Published in: The American journal of pathology Vol. 188; no. 4; pp. 904 - 915
• Main Authors: Clancy, Chad S., Van Wettere, Arnaud J., Siddharthan, Venkatraman, Morrey, John D., Julander, Justin G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018; American Society for Investigative Pathology
• Subjects: Acute Disease; Animals; Epididymis - pathology; Genitalia, Male - pathology; Genitalia, Male - virology; Inflammation - pathology; Male; Mice, Knockout; Receptor, Interferon alpha-beta - deficiency; Receptor, Interferon alpha-beta - metabolism; RNA, Viral - analysis; Testis - pathology; Zika Virus - physiology; Zika Virus Infection - pathology; Zika Virus Infection - virology

An understanding of the pathogenesis of infection with the Zika virus in the male reproductive tract is vital for the development of vaccines and antivirals that will limit or prevent sexual transmission. Two common immunocompromised mouse strains used in transmission studies—male with genes encodin...