The role of AMPK in regulation of Na+,K+-ATPase in skeletal muscle: does the gauge always plug the sink?

• Published in: Journal of muscle research and cell motility Vol. 42; no. 1; pp. 77 - 97
• Main Authors: Pirkmajer, Sergej, Petrič, Metka, Chibalin, Alexander V.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.03.2021; Springer Nature B.V
• Subjects: Adaptation; Alveoli; AMP; AMP-activated protein kinase; Animal Anatomy; Biomedical and Life Sciences; Biomedicine; Cell Biology; Endocytosis; Energy; Energy balance; Excitability; Histology; Homeostasis; Kinases; Life Sciences; Medicin och hälsovetenskap; Morphology; Muscle contraction; Musculoskeletal system; Na+/K+-exchanging ATPase; Nutrient uptake; Nutrients; Proteomics; Review; Skeletal muscle; AMPK; Energy metabolism; Na; K; ATPase; Skeletal muscle; Na+, K+-ATPase

AMP-activated protein kinase (AMPK) is a cellular energy gauge and a major regulator of cellular energy homeostasis. Once activated, AMPK stimulates nutrient uptake and the ATP-producing catabolic pathways, while it suppresses the ATP-consuming anabolic pathways, thus helping to maintain the cellula...