Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease

• Published in: Blood Vol. 128; no. 16; pp. 2033 - 2042
• Main Authors: Montenont, Emilie, Echagarruga, Christina, Allen, Nicole, Araldi, Elisa, Suarez, Yajaira, Berger, Jeffrey S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.10.2016; American Society of Hematology
• Subjects: Adult; Atherosclerosis - genetics; Atherosclerosis - metabolism; Atherosclerosis - pathology; Blood Platelets - metabolism; Blood Platelets - pathology; Cell Line; Cytoskeleton - genetics; Cytoskeleton - metabolism; Cytoskeleton - pathology; Female; Gene Expression Regulation; Humans; Male; Megakaryocytes - metabolism; Megakaryocytes - pathology; Microfilament Proteins - biosynthesis; Microfilament Proteins - genetics; Platelet Adhesiveness; Platelets and Thrombopoiesis

Platelet activity plays a major role in hemostasis with increased platelet activity likely contributing to the pathogenesis of atherothrombosis. We sought to identify associations between platelet activity variability and platelet-related genes in healthy controls. Transcriptional profiling of plate...