Updates on Hydroxychloroquine in Prevention and Treatment of COVID-19

Saved in:
Bibliographic Details
Published inThe American journal of medicine Vol. 135; no. 1; pp. 7 - 9
Main Authors Hennekens, Charles H., Rane, Manas, Solano, Joshua, Alter, Scott, Johnson, Heather, Krishnaswamy, Shiv, Shih, Richard, Maki, Dennis, DeMets, David L.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.2022
Subjects
Antimalarials - administration & dosage
Antimalarials - adverse effects
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - prevention & control
Chemoprevention - adverse effects
Chemoprevention - methods
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 Drug Treatment
Humans
Hydroxychloroquine - administration & dosage
Hydroxychloroquine - adverse effects
Randomized Controlled Trials as Topic
Risk Assessment
SARS-CoV-2
Online AccessGet full text

Cover

Author Maki, Dennis
Johnson, Heather
Alter, Scott
DeMets, David L.
Hennekens, Charles H.
Rane, Manas
Krishnaswamy, Shiv
Solano, Joshua
Shih, Richard
Author_xml – sequence: 1
  givenname: Charles H.
  orcidid: 0000-0003-1214-1663
  surname: Hennekens
  fullname: Hennekens, Charles H.
  email: chenneke@health.fau.edu
  organization: Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton
– sequence: 2
  givenname: Manas
  surname: Rane
  fullname: Rane, Manas
  organization: PGY-5, Harvard Medical School and Brigham and Women's Hospital and VA Boston Healthcare System, Boston, Mass
– sequence: 3
  givenname: Joshua
  surname: Solano
  fullname: Solano, Joshua
  organization: Department of Emergency Medicine, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton
– sequence: 4
  givenname: Scott
  orcidid: 0000-0003-3824-6308
  surname: Alter
  fullname: Alter, Scott
  organization: Department of Emergency Medicine, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton
– sequence: 5
  givenname: Heather
  orcidid: 0000-0002-4916-3519
  surname: Johnson
  fullname: Johnson, Heather
  organization: Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton
– sequence: 6
  givenname: Shiv
  surname: Krishnaswamy
  fullname: Krishnaswamy, Shiv
  organization: Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton
– sequence: 7
  givenname: Richard
  orcidid: 0000-0003-4777-6343
  surname: Shih
  fullname: Shih, Richard
  organization: Department of Emergency Medicine, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton
– sequence: 8
  givenname: Dennis
  surname: Maki
  fullname: Maki, Dennis
  organization: COVID-19 Intensive Care Unit, University of Wisconsin School of Medicine & Public Health, Madison
– sequence: 9
  givenname: David L.
  surname: DeMets
  fullname: DeMets, David L.
  organization: Biostatistics & Medical Informatics, University of Wisconsin-Madison School of Medicine & Public Health, Madison
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34437834$$D View this record in MEDLINE/PubMed
BookMark eNp9kMtOwzAQRS1URB_wBwjlBxLs2M5jg4RKoZUqlUXL1nL8oI4auzihon-Pq0KBDauRZ3zv3DlD0LPOKgCuEUwQRNltnfCmbpRMUpiiBOYJxPQMDBClNM5RlvbAAEKYxiUmuA-GbVuHJyxpdgH6mBCcF5gMwGS1lbxTbeRsNN1L7z72Yr1x3r29G6siY6Nnr3bKdiZ84FZGS69414RG5HQ0XrzMHmJUXoJzzTetuvqqI7B6nCzH03i-eJqN7-exIBnuYsoxqSpdVJpLCSuV5SRPCSml5iiFmpe8oIhCrQTWGpUhLEK8yqlQEqMyx3gE7o6-2_cqnC5CDM83bOtNw_2eOW7Y34k1a_bqdqzARUBCgwE5Ggjv2tYrfdIiyA5YWc2OWNkBK4M5C1iD7Ob33pPom-NPMBWu3xnlWSuMsiG48Up0TDrz_4ZPsgmN8A
CitedBy_id crossref_primary_10_1371_journal_pone_0291373
crossref_primary_10_3390_covid2030018
crossref_primary_10_3390_ijtm3020015
crossref_primary_10_1080_07853890_2023_2265298
crossref_primary_10_1016_j_molimm_2023_03_009
crossref_primary_10_1016_j_virusres_2024_199419
crossref_primary_10_3390_microorganisms11041000
crossref_primary_10_3389_fmed_2023_1202504
crossref_primary_10_1177_08971900241228762
crossref_primary_10_3390_vaccines10122150
crossref_primary_10_1002_mog2_58
crossref_primary_10_1016_j_mib_2024_102437
crossref_primary_10_12688_wellcomeopenres_20976_1
crossref_primary_10_1097_CCM_0000000000006271
Cites_doi 10.1056/NEJMoa2022926
10.1038/s41421-020-0156-0
10.7326/M20-6519
10.1056/NEJMoa2023184
10.7326/M20-1223
10.1056/NEJMoa2016638
10.1001/jama.2009.1756
10.1016/j.amjmed.2020.05.005
10.1001/jama.2011.322
10.1056/NEJMoa2021801
ContentType Journal Article
Copyright 2021 Elsevier Inc.
2021 Elsevier Inc. All rights reserved. 2021 Elsevier Inc.
Copyright_xml – notice: 2021 Elsevier Inc.
– notice: 2021 Elsevier Inc. All rights reserved. 2021 Elsevier Inc.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
5PM
DOI 10.1016/j.amjmed.2021.07.035
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1555-7162
EndPage 9
ExternalDocumentID 10_1016_j_amjmed_2021_07_035
34437834
S0002934321005234
Genre Editorial
GroupedDBID ---
--K
-~X
.-4
.1-
.55
.FO
.GJ
0R~
123
1B1
1CY
1P~
1RT
1~5
23M
3O-
4.4
457
4CK
4G.
53G
5RE
5VS
6J9
7-5
AACTN
AAEDT
AAEDW
AAIAV
AALRI
AAQFI
AAQQT
AAQXK
AAWTL
AAXUO
AAYOK
ABLJU
ABMAC
ABOCM
ABPPZ
ACGFO
ACIUM
ACKOT
ACPRK
ADBBV
ADMUD
ADPAM
AENEX
AEVXI
AFFNX
AFHKK
AFRHN
AFTJW
AGHFR
AGZHU
AHHHB
AHMBA
AHPSJ
AITUG
AJUYK
ALMA_UNASSIGNED_HOLDINGS
ALXNB
AMRAJ
ASPBG
AVWKF
AZFZN
BELOY
BKOMP
C5W
CS3
EBS
EFJIC
EJD
EX3
F5P
FDB
FEDTE
FGOYB
FIRID
G-2
G-Q
GBLVA
HEA
HMK
HMO
HVGLF
HZ~
IH2
IHE
J1W
J5H
K-O
KOM
L7B
LZ2
M29
M41
MO0
MVM
N4W
N9A
NCXOZ
NQ-
O9-
OD.
OHT
OO~
P2P
PC.
PQQKQ
R2-
RIG
ROL
RPZ
SAE
SEL
SES
SSZ
TWZ
UBY
UHB
UHU
UNMZH
UV1
WH7
WOW
WUQ
X7M
XH2
XPP
YFH
YOC
YQJ
YYQ
Z5R
ZA5
ZGI
ZUP
ZXP
0SF
ADVLN
AFCTW
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
5PM
ID FETCH-LOGICAL-c463t-5a34bbf8bfadd0be67472449dfa120fa9a85150fec3ff1909511ab75ced319733
ISSN 0002-9343
IngestDate Tue Sep 17 21:13:29 EDT 2024
Fri Aug 23 02:12:48 EDT 2024
Tue Aug 27 13:49:49 EDT 2024
Fri Feb 23 02:41:29 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c463t-5a34bbf8bfadd0be67472449dfa120fa9a85150fec3ff1909511ab75ced319733
ORCID 0000-0003-4777-6343
0000-0003-1214-1663
0000-0003-3824-6308
0000-0002-4916-3519
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC8381625
PMID 34437834
PageCount 3
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8381625
crossref_primary_10_1016_j_amjmed_2021_07_035
pubmed_primary_34437834
elsevier_sciencedirect_doi_10_1016_j_amjmed_2021_07_035
PublicationCentury 2000
PublicationDate 2022-01-01
PublicationDateYYYYMMDD 2022-01-01
PublicationDate_xml – month: 01
  year: 2022
  text: 2022-01-01
  day: 01
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle The American journal of medicine
PublicationTitleAlternate Am J Med
PublicationYear 2022
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Hennekens, DeMets (bib0005) 2011; 305
Hennekens, Buring (bib0006) 1987
Kim, Sparks, Liew (bib0013) 2020; 172
Funk G, Gramlich J. Amid coronavirus threat, Americans generally have a high level of trust in medical doctors. Pew Research Center. Published March 13, 2020. Available at
Horby, Mafham (bib0010) 2020; 383
Accessed July 13, 2021.
Pan, Peto (bib0011) 2021; 384
Barnabas, Brown, Bershteyn (bib0009) 2021; 174
Shih, Johnson, Maki, Hennekens (bib0003) 2020; 133
Jones JLM, Jenny BE, Bergs M. Drug diagnosis code data sought by old HHS OIG may cue enforcement. Bloomberg Law. Published July 12, 2021. Available at
Liu, Cao, Xu (bib0004) 2020; 6
Monne, Suner, Tebe (bib0008) 2021; 384
Hennekens, DeMets (bib0012) 2009; 302
Boulware, Pullen, Bangdiwala (bib0007) 2020; 383
Liu (10.1016/j.amjmed.2021.07.035_bib0004) 2020; 6
Horby (10.1016/j.amjmed.2021.07.035_bib0010) 2020; 383
Monne (10.1016/j.amjmed.2021.07.035_bib0008) 2021; 384
Pan (10.1016/j.amjmed.2021.07.035_bib0011) 2021; 384
10.1016/j.amjmed.2021.07.035_bib0001
Hennekens (10.1016/j.amjmed.2021.07.035_bib0005) 2011; 305
10.1016/j.amjmed.2021.07.035_bib0002
Shih (10.1016/j.amjmed.2021.07.035_bib0003) 2020; 133
Hennekens (10.1016/j.amjmed.2021.07.035_bib0012) 2009; 302
Boulware (10.1016/j.amjmed.2021.07.035_bib0007) 2020; 383
Barnabas (10.1016/j.amjmed.2021.07.035_bib0009) 2021; 174
Kim (10.1016/j.amjmed.2021.07.035_bib0013) 2020; 172
Hennekens (10.1016/j.amjmed.2021.07.035_bib0006) 1987
References_xml – volume: 384
  start-page: 417
  year: 2021
  end-page: 427
  ident: bib0008
  article-title: A cluster-randomized trial of hydroxychloroquine as prevention of Covid-19 transmission and disease
  publication-title: N Engl J Med
  contributor:
    fullname: Tebe
– volume: 133
  start-page: 1007
  year: 2020
  end-page: 1008
  ident: bib0003
  article-title: Hydroxychloroquine for coronavirus: the urgent need for a moratorium on prescriptions
  publication-title: Am J Med
  contributor:
    fullname: Hennekens
– volume: 6
  start-page: 16
  year: 2020
  ident: bib0004
  article-title: Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
  publication-title: Cell Discov
  contributor:
    fullname: Xu
– year: 1987
  ident: bib0006
  article-title: Epidemiology in Medicine
  contributor:
    fullname: Buring
– volume: 172
  start-page: 819
  year: 2020
  end-page: 821
  ident: bib0013
  article-title: A rush to judgment? Rapid reporting and dissemination of results and its consequences regarding the use of hydroxychloroquine for COVID-19
  publication-title: Ann Intern Med
  contributor:
    fullname: Liew
– volume: 174
  start-page: 344
  year: 2021
  end-page: 352
  ident: bib0009
  article-title: Hydroxychloroquine as postexposure prophylaxis to prevent severe acute respiratory syndrome in coronary virus 2 infection: a randomized trial
  publication-title: Ann Intern Med
  contributor:
    fullname: Bershteyn
– volume: 383
  start-page: 517
  year: 2020
  end-page: 525
  ident: bib0007
  article-title: A randomized trial of hydroxychloroquine as post exposure prophylaxis for Covid-19
  publication-title: N Engl J Med
  contributor:
    fullname: Bangdiwala
– volume: 302
  start-page: 2361
  year: 2009
  end-page: 2362
  ident: bib0012
  article-title: The need for large scale randomized evidence without undue emphasis on small trials, meta-analyses or subgroup analyses
  publication-title: JAMA
  contributor:
    fullname: DeMets
– volume: 305
  start-page: 1134
  year: 2011
  end-page: 1136
  ident: bib0005
  article-title: Statistical association and causation: contributions of different types of evidence
  publication-title: JAMA
  contributor:
    fullname: DeMets
– volume: 383
  start-page: 2030
  year: 2020
  end-page: 2040
  ident: bib0010
  article-title: Effect of hydroxychloroquine in hospitalized patients with Covid-19
  publication-title: N Engl J Med
  contributor:
    fullname: Mafham
– volume: 384
  start-page: 497
  year: 2021
  end-page: 511
  ident: bib0011
  article-title: Repurposed antiviral drugs for Covid-19-Interim WHO Solidarity Trial results
  publication-title: N Engl J Med
  contributor:
    fullname: Peto
– volume: 383
  start-page: 2030
  issue: 21
  year: 2020
  ident: 10.1016/j.amjmed.2021.07.035_bib0010
  article-title: Effect of hydroxychloroquine in hospitalized patients with Covid-19
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2022926
  contributor:
    fullname: Horby
– volume: 6
  start-page: 16
  year: 2020
  ident: 10.1016/j.amjmed.2021.07.035_bib0004
  article-title: Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
  publication-title: Cell Discov
  doi: 10.1038/s41421-020-0156-0
  contributor:
    fullname: Liu
– volume: 174
  start-page: 344
  issue: 3
  year: 2021
  ident: 10.1016/j.amjmed.2021.07.035_bib0009
  article-title: Hydroxychloroquine as postexposure prophylaxis to prevent severe acute respiratory syndrome in coronary virus 2 infection: a randomized trial
  publication-title: Ann Intern Med
  doi: 10.7326/M20-6519
  contributor:
    fullname: Barnabas
– volume: 384
  start-page: 497
  issue: 6
  year: 2021
  ident: 10.1016/j.amjmed.2021.07.035_bib0011
  article-title: Repurposed antiviral drugs for Covid-19-Interim WHO Solidarity Trial results
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2023184
  contributor:
    fullname: Pan
– volume: 172
  start-page: 819
  issue: 12
  year: 2020
  ident: 10.1016/j.amjmed.2021.07.035_bib0013
  article-title: A rush to judgment? Rapid reporting and dissemination of results and its consequences regarding the use of hydroxychloroquine for COVID-19
  publication-title: Ann Intern Med
  doi: 10.7326/M20-1223
  contributor:
    fullname: Kim
– volume: 383
  start-page: 517
  year: 2020
  ident: 10.1016/j.amjmed.2021.07.035_bib0007
  article-title: A randomized trial of hydroxychloroquine as post exposure prophylaxis for Covid-19
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2016638
  contributor:
    fullname: Boulware
– ident: 10.1016/j.amjmed.2021.07.035_bib0002
– volume: 302
  start-page: 2361
  issue: 21
  year: 2009
  ident: 10.1016/j.amjmed.2021.07.035_bib0012
  article-title: The need for large scale randomized evidence without undue emphasis on small trials, meta-analyses or subgroup analyses
  publication-title: JAMA
  doi: 10.1001/jama.2009.1756
  contributor:
    fullname: Hennekens
– ident: 10.1016/j.amjmed.2021.07.035_bib0001
– volume: 133
  start-page: 1007
  issue: 9
  year: 2020
  ident: 10.1016/j.amjmed.2021.07.035_bib0003
  article-title: Hydroxychloroquine for coronavirus: the urgent need for a moratorium on prescriptions
  publication-title: Am J Med
  doi: 10.1016/j.amjmed.2020.05.005
  contributor:
    fullname: Shih
– volume: 305
  start-page: 1134
  issue: 11
  year: 2011
  ident: 10.1016/j.amjmed.2021.07.035_bib0005
  article-title: Statistical association and causation: contributions of different types of evidence
  publication-title: JAMA
  doi: 10.1001/jama.2011.322
  contributor:
    fullname: Hennekens
– year: 1987
  ident: 10.1016/j.amjmed.2021.07.035_bib0006
  contributor:
    fullname: Hennekens
– volume: 384
  start-page: 417
  year: 2021
  ident: 10.1016/j.amjmed.2021.07.035_bib0008
  article-title: A cluster-randomized trial of hydroxychloroquine as prevention of Covid-19 transmission and disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2021801
  contributor:
    fullname: Monne
SSID ssj0000956
Score 2.47895
SourceID pubmedcentral
crossref
pubmed
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 7
SubjectTerms Antimalarials - administration & dosage
Antimalarials - adverse effects
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - epidemiology
Arrhythmias, Cardiac - prevention & control
Chemoprevention - adverse effects
Chemoprevention - methods
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 Drug Treatment
Humans
Hydroxychloroquine - administration & dosage
Hydroxychloroquine - adverse effects
Randomized Controlled Trials as Topic
Risk Assessment
SARS-CoV-2
Title Updates on Hydroxychloroquine in Prevention and Treatment of COVID-19
URI https://dx.doi.org/10.1016/j.amjmed.2021.07.035
https://www.ncbi.nlm.nih.gov/pubmed/34437834
https://pubmed.ncbi.nlm.nih.gov/PMC8381625
Volume 135
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKJiFeEN-MAfIDbyhVEtv5eKzGUGACJNrC3qI4sdV2kE5bK7H99dzFjpNskwZ7iaqkTdy7y_l3H_6ZkHcRwFwZ8coDbC8hQFEVvlK-J3SZBlwHOMlgt8XXKJvzz8fieDT60-ta2m7kuLy8cV3JXbQK50CvuEr2PzTrbgon4DPoF46gYTj-k47npxivNwn_7KLChpRyAfE3-PqlIQNpCZpsy_HMdZVjE8a3H58-eNaTrDqjcTWcHqnE1Qp8hu75RNXnvYr9-2zcFY1MnhR7axxmn0IQXa9t1WGxddPB5JfdG2SKNBH9LEQYXslCuOUxg-7Nxt2mzPAwjZX1sEJ4SFs1cMGGsmRga8ahxr2ZOb3R5Zvsw2pc_F6BMCDiD4OGjtXeckimPcUh4Ygg0sWEOL9HdsM4FRC2706Ovv886mbxtNn51_2Fdtll0xt4_Vm3wpphy20Pw8wekYc2-KATY0mPyUjVT8j9L1a5T8mhNSi6rul1g6LLmnYGRcGgqDMouta0NahnZP7xcHaQeXafDa_kEdt4omBcSp1IDZOdL1UEISagvrTSRRD6ukgLgOXC16pkWgOABFAeFDIWparAgceMPSc79bpWLwktI61lwhTEnZpXqkgKyVNWqEQoLpSSe8RrxZSfGjqVvO0zXOVGrDmKNffjHMS6R-JWlrmFhAbq5aD-W375wkjcPYdxznBbGbjnQBfuC8i0PrxSLxcN43qC5fVQvLrzaPbJg-6teU12Nmdb9QbQ7Ea-tYb3FyLQoUY
link.rule.ids 230,315,786,790,891,27957,27958
linkProvider Library Specific Holdings
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Updates+on+Hydroxychloroquine+in+Prevention+and+Treatment+of+COVID-19&rft.jtitle=The+American+journal+of+medicine&rft.au=Hennekens%2C+Charles+H.&rft.au=Rane%2C+Manas&rft.au=Solano%2C+Joshua&rft.au=Alter%2C+Scott&rft.date=2022-01-01&rft.pub=Elsevier+Inc&rft.issn=0002-9343&rft.eissn=1555-7162&rft.volume=135&rft.issue=1&rft.spage=7&rft.epage=9&rft_id=info:doi/10.1016%2Fj.amjmed.2021.07.035&rft.externalDocID=S0002934321005234
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9343&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9343&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9343&client=summon