Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα

• Published in: Molecular biology of the cell Vol. 25; no. 10; pp. 1686 - 1697
• Main Authors: Baird, Thomas D., Palam, Lakshmi Reddy, Fusakio, Michael E., Willy, Jeffrey A., Davis, Christopher M., McClintick, Jeanette N., Anthony, Tracy G., Wek, Ronald C.
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 15.05.2014
• Subjects: Activating Transcription Factor 4 - genetics; Animals; Base Sequence; Carrier Proteins - biosynthesis; Carrier Proteins - genetics; Caspase 3 - metabolism; Caspase 7 - metabolism; Cell Division - genetics; Cell Line; Cell Survival - genetics; eIF-2 Kinase - genetics; Endoplasmic Reticulum - metabolism; Endoplasmic Reticulum Stress - genetics; Gene Expression Regulation; Hep G2 Cells; Humans; Mice; Molecular Sequence Data; Open Reading Frames - genetics; Phosphorylation; Protein Biosynthesis - genetics; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; RNA Interference; RNA, Messenger - genetics; RNA, Small Interfering; Transcription Factor CHOP - genetics; Transcription Initiation Site; Transcriptional Activation - genetics; Unfolded Protein Response - genetics

Disruption of protein folding in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a transcriptional and translational control network designed to restore protein homeostasis. Central to the UPR is PKR-like ER kinase (PERK/EIF2AK3) phosphorylation of the α subunit of eIF2...