Plasma Brain-Derived Neurotrophic Factor as a Peripheral Marker for the Action Mechanism of Antidepressants

• Published in: Neuropsychobiology Vol. 57; no. 4; pp. 194 - 199
• Main Authors: Lee, Hwa-Young, Kim, Yong-Ku
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2008
• Subjects: Adult; Antidepressive Agents - blood; Antidepressive Agents - therapeutic use; Biomarkers - blood; Brain-Derived Neurotrophic Factor - blood; Brain-Derived Neurotrophic Factor - drug effects; Case-Control Studies; Chi-Square Distribution; Citalopram - blood; Citalopram - therapeutic use; Cyclohexanols - blood; Cyclohexanols - therapeutic use; Depressive Disorder, Major - blood; Depressive Disorder, Major - drug therapy; Female; Humans; Male; Matched-Pair Analysis; Neuropsychological Tests; Original Paper; Paroxetine - blood; Paroxetine - therapeutic use; Reference Values; Severity of Illness Index; Treatment Outcome; Venlafaxine Hydrochloride; Major depressive disorder; Brain-derived neurotrophic factor; Antidepressant treatment

Numerous studies have demonstrated that depression is associated with a decreased expression of brain-derived neurotrophic factor (BDNF). BDNF shows antidepressant-like effects in animal models. Therefore, we tested the hypothesis that BDNF might be a peripheral marker for the mechanism of action of...