Cost-Effectiveness of Exome Sequencing versus Targeted Gene Panels for Prenatal Diagnosis of Fetal Effusions and Non-Immune Hydrops Fetalis

• Published in: American journal of obstetrics & gynecology MFM Vol. 4; no. 6; p. 100724
• Main Authors: Avram, Carmen M., Caughey, Aaron B., Norton, Mary E., Sparks, Teresa N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2022
• Subjects: Cost-Benefit Analysis; cost-effectiveness; Exome Sequencing; Female; Fetal Diseases - diagnosis; Fetal Diseases - genetics; Humans; Hydrops Fetalis - diagnosis; Hydrops Fetalis - genetics; Infant; Infant, Newborn; nonimmune hydrops fetalis; Perinatal Death; Pregnancy; prenatal diagnosis; Prenatal Diagnosis - methods; Stillbirth; cost-effectiveness; exome sequencing; prenatal diagnosis; nonimmune hydrops fetalis

Although exome sequencing has a greater overall diagnostic yield than targeted gene panels in the evaluation of nonimmune hydrops fetalis and fetal effusions, the cost-effectiveness of this approach is not known. This study aimed to evaluate the costs and outcomes of targeted gene panels vs exome se...