Upregulation of NOX2 and NOX4 Mediated by TGF-β Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury

• Published in: Cellular physiology and biochemistry Vol. 46; no. 5; pp. 2103 - 2113
• Main Authors: Lou, Zheng, Wang, Ai-Ping, Duan, Xiao-Ming, Hu, Guo-Huang, Song, Gui-Lin, Zuo, Mei-Ling, Yang, Zhong-Bao
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: ALK5; Animals; Benzodioxoles - therapeutic use; Brain; Brain Ischemia - drug therapy; Brain Ischemia - genetics; Brain Ischemia - metabolism; Brain Ischemia - pathology; Carotid arteries; Cerebral ischemia/reperfusion injury; Growth factors; Hypoxia; Imidazoles - therapeutic use; Ischemia; Kinases; Laboratory animals; Male; NADPH Oxidase 2 - genetics; NADPH Oxidase 2 - metabolism; NADPH Oxidase 4 - genetics; NADPH Oxidase 4 - metabolism; Neurodegeneration; Neurosciences; NOX2; NOX4; Original Paper; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; PC12 Cells; Proteins; Pyridines - therapeutic use; Rats; Rats, Sprague-Dawley; Reactive oxygen species; Reperfusion Injury - drug therapy; Reperfusion Injury - genetics; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Rodents; ROS; Signal Transduction; TGF-β signaling; Transforming Growth Factor beta - metabolism; Up-Regulation; Veins & arteries; NOX4; Cerebral ischemia/reperfusion injury; ALK5; TGF-β signaling; ROS; NOX2

Background/Aims: Ischemic stroke is still one of the leading debilitating diseases with high morbidity and mortality. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) play an important role in cerebral ischemia/reperfusion (I/R) injury. However, the mechanism underlying the regulation of RO...