Upregulation of NOX2 and NOX4 Mediated by TGF-β Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury - Lou, Zheng; Wang, Ai-Ping; Duan, Xiao-Ming; Hu, Guo-Huang; Song, Gui-Lin; Zuo, Mei-Ling; Yang, Zhong-Bao (Cellular physiology and biochemistry, 2018)
Keywords: ALK5; Animals; Benzodioxoles - therapeutic use; Brain; Brain Ischemia - drug therapy; Brain Ischemia - genetics; Brain Ischemia - metabolism; Brain Ischemia - pathology; Carotid arteries; Cerebral ischemia/reperfusion injury; Growth factors; Hypoxia; Imidazoles - therapeutic use; Ischemia; Kinases; Laboratory animals; Male; NADPH Oxidase 2 - genetics; NADPH Oxidase 2 - metabolism; NADPH Oxidase 4 - genetics; NADPH Oxidase 4 - metabolism; Neurodegeneration; Neurosciences; NOX2; NOX4; Original Paper; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; PC12 Cells; Proteins; Pyridines - therapeutic use; Rats; Rats, Sprague-Dawley; Reactive oxygen species; Reperfusion Injury - drug therapy; Reperfusion Injury - genetics; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Rodents; ROS; Signal Transduction; TGF-β signaling; Transforming Growth Factor beta - metabolism; Up-Regulation; Veins & arteries; NOX4; Cerebral ischemia/reperfusion injury; ALK5; TGF-β signaling; ROS; NOX2