Hemoglobin Is Expressed by Mesangial Cells and Reduces Oxidant Stress

• Published in: Journal of the American Society of Nephrology Vol. 19; no. 8; pp. 1500 - 1508
• Main Authors: NISHI, Hiroshi, INAGI, Reiko, KATO, Hideki, TANEMOTO, Masayuki, KOJIMA, Ichiro, SON, Daisuke, FUJITA, Toshiro, NANGAKU, Masaomi
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.08.2008; American Society of Nephrology
• Subjects: Animals; Basic Research; Biological and medical sciences; Cells, Cultured; Fluorescent Antibody Technique; Fundamental and applied biological sciences. Psychology; Gene Expression; Hemoglobins - genetics; Hemoglobins - metabolism; Hypoxia - metabolism; Immunoblotting; In Situ Hybridization; Male; Medical sciences; Mesangial Cells - metabolism; Nephrology. Urinary tract diseases; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Vertebrates: urinary system; Oxidative stress; Nephrology; Rat; Mesangial cell; Rodentia; Kidney; Urology; Renal glomerulus; Vertebrata; Mammalia; Urinary system; Animal; Hemoglobin

Hemoglobin (Hb) serves as the main oxygen transporter in erythrocytes, but it is also expressed in nonhematopoietic organs, where it serves an unknown function. In this study, microarray and proteomic analyses demonstrated Hb expression in the kidney. Rat kidneys were perfused extensively with salin...