The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC

• Published in: Cell reports (Cambridge) Vol. 41; no. 10; p. 111759
• Main Authors: Lee, Ji-Sun, Lero, Michael W., Mercado-Matos, Jose, Zhu, Sha, Jo, Minjeong, Tocheny, Claire E., Morgan, Jennifer S., Shaw, Leslie M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.12.2022
• Subjects: breast cancer; cancer stem cell; CSC; IGF; Insulin; insulin receptor substrate; insulin-like growth factor; IRS2; MYC; Neoplasms; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; PI3K; Signal Transduction; Somatomedins; CSC; insulin; cancer stem cell; PI3K; MYC; CP: Cancer; IGF; breast cancer; insulin-like growth factor; IRS2; insulin receptor substrate

Despite the strong association of the insulin/insulin-like growth factor (IGF) signaling (IIS) pathway with tumor initiation, recurrence, and metastasis, the mechanism by which this pathway regulates cancer progression is not well understood. Here, we report that IIS supports breast cancer stem cell...