Molecular Pathogenesis of Oral Squamous Cell Carcinoma : Implications for Therapy

• Published in: Journal of dental research Vol. 87; no. 1; pp. 14 - 32
• Main Authors: Choi, S., Myers, J.N.
• Format: Journal Article
• Language: English
• Published: United States SAGE Publications 01.01.2008; SAGE PUBLICATIONS, INC
• Subjects: Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - therapy; Environment; Gene Expression Regulation - genetics; Genes, Tumor Suppressor - physiology; Genetic Predisposition to Disease; Genetic Therapy; Humans; Molecular Biology; molecular targeted therapy; Mouth Neoplasms - genetics; Mouth Neoplasms - therapy; multistep carcinogenesis; oncogene; Oncogenes - physiology; oral squamous cell carcinoma; tumor suppressor gene; multistep carcinogenesis; oral squamous cell carcinoma; molecular targeted therapy; oncogene; tumor suppressor gene

The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring the accumulation of multiple genetic alterations, influenced by a patient’s genetic predisposition as well as by environmental influences, including tobacco, alcohol, chronic inflammation, and viral infection. Tu...