Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth

• Published in: The Journal of clinical investigation Vol. 116; no. 1; pp. 101 - 114
• Main Authors: Dong, Xiaocheng, Park, Sunmin, Lin, Xueying, Copps, Kyle, Yi, Xianjin, White, Morris F.
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.01.2006
• Subjects: Animals; Apoptosis; Biomedical research; Body Weight; Bone Density; Diabetes; Fatty acids; Genes; Glucose; Glucose - metabolism; Homeostasis; Hyperglycemia; Hypothalamus; Insulin Receptor Substrate Proteins; Insulin resistance; Intracellular Signaling Peptides and Proteins; Kinases; Liver; Liver - cytology; Liver - physiology; Metabolism; Mice; Mice, Knockout; Organ Size; Pancreas - physiology; Phosphoproteins - deficiency; Phosphoproteins - genetics; Phosphoproteins - physiology; Phosphorylation; Proteins; Receptor, Insulin - physiology; Signal Transduction

Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF receptor signals with heterologous pathways to coordinate growth and metabolism. Since Irs2 is thought to be especially important in hepatic nutrient homeostasis, we deleted Irs2 [corrected] from hepatocytes of WT mice (...