DNA damage and repair activity after broccoli intake in young healthy smokers

• Published in: Mutagenesis Vol. 25; no. 6; pp. 595 - 602
• Main Authors: Riso, Patrizia, Martini, Daniela, Møller, Peter, Loft, Steffen, Bonacina, Gaia, Moro, Massimo, Porrini, Marisa
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2010
• Subjects: Adult; Biological and medical sciences; Brassica; Brassica - chemistry; Brassica - physiology; Diet; DNA Breaks - drug effects; DNA Damage - drug effects; DNA Damage - physiology; DNA Repair - drug effects; DNA Repair - genetics; DNA Repair - physiology; DNA Repair Enzymes - genetics; DNA Repair Enzymes - metabolism; Eating - physiology; Enzyme Activation - drug effects; Fundamental and applied biological sciences. Psychology; Health; Humans; Male; Molecular and cellular biology; Molecular genetics; Mutagenesis. Repair; Polymorphism, Genetic - physiology; Smoking - genetics; Smoking - metabolism; Young Adult; Lesion; Mutagenesis; Repair; Smoker; DNA; Tobacco smoking

Cruciferous vegetables contain compounds with antioxidant properties (e.g. carotenoids, vitamin C and folates) and can alter the activity of xenobiotic metabolism (i.e. isothiocyanates). These constituents may be particularly important for subjects who are exposed to free radicals and genotoxic comp...