BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras -Mutant Non-Small Cell Lung Cancer

• Published in: Cancer immunology research Vol. 6; no. 10; p. 1234
• Main Authors: Adeegbe, Dennis O, Liu, Shengwu, Hattersley, Maureen M, Bowden, Michaela, Zhou, Chensheng W, Li, Shuai, Vlahos, Raven, Grondine, Michael, Dolgalev, Igor, Ivanova, Elena V, Quinn, Max M, Gao, Peng, Hammerman, Peter S, Bradner, James E, Diehl, J Alan, Rustgi, Anil K, Bass, Adam J, Tsirigos, Aristotelis, Freeman, Gordon J, Chen, Huawei, Wong, Kwok-Kin
• Format: Journal Article
• Language: English
• Published: United States 01.10.2018

mutation is present in approximately 30% of human lung adenocarcinomas. Although recent advances in targeted therapy have shown great promise, effective targeting of KRAS remains elusive, and concurrent alterations in tumor suppressors render mutant tumors even more resistant to existing therapies....