Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage

• Published in: Experimental neurology Vol. 187; no. 2; pp. 299 - 309
• Main Authors: Carter, Troy L., Rissman, Robert A., Mishizen-Eberz, Amanda J., Wolfe, Barry B., Hamilton, Ronald L., Gandy, Sam, Armstrong, David M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.06.2004; Elsevier
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; AMPA receptor; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Progression; Excitotoxicity; Female; Glutamate; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Hippocampus; Hippocampus - metabolism; Hippocampus - pathology; Humans; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Neurology; Protein Subunits - analysis; Protein Subunits - biosynthesis; Receptors, AMPA - analysis; Receptors, AMPA - biosynthesis; Severity of Illness Index; Western blot; Western blot; AMPA receptor; Glutamate; Alzheimer's disease; Excitotoxicity; Hippocampus; Toxicity; Alzheimer disease; Central nervous system; Homeostasis; Glutamate receptor; Immunoblotting assay; Degenerative disease; Receptor protein; Human; Nervous system diseases; Preservation; Ions; Vulnerability; Neurofibrillary tangle; Cerebral disorder; Anatomic pathology; Dentate gyrus; Neuron; Central nervous system disease; Excitatory aminoacid; Neurotransmitter; Intracellular

The Alzheimer's disease (AD) brain, characterized pathologically by the presence of senile plaques and neurofibrillary tangles, contains regions that are differentially prone toward development of AD pathology. Within these “vulnerable” regions, specific cell populations appear to be selectivel...