Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”), a condition that significantly impairs the quality of life of many cancer survivors

• Published in: Biochimica et biophysica acta. Molecular basis of disease Vol. 1865; no. 6; pp. 1088 - 1097
• Main Authors: Ren, Xiaojia, Boriero, Diana, Chaiswing, Luksana, Bondada, Subbarao, St. Clair, Daret K., Butterfield, D. Allan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2019
• Subjects: Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Blood-brain barrier; Brain - drug effects; Brain - pathology; Brain - physiopathology; Cancer Survivors - psychology; Cancer Survivors - statistics & numerical data; Chemotherapy-induced cognitive impairment; Cognitive Dysfunction - chemically induced; Cognitive Dysfunction - physiopathology; Humans; Memory - drug effects; Mitochondrial dysfunction; Models, Biological; Neoplasms - drug therapy; Neoplasms - physiopathology; Neoplasms - psychology; Oxidative damage; Oxidative Stress - drug effects; Quality of Life; TNF-alpha; APE1/APEX1; BBB; TNF-alpha; OGG1; MDA; COMT; NF-κB; Blood-brain barrier; RNS; iNOS; JAK2; AD; cyt c; Dox; IL-1β; IL-6; AP; NOR; P-pg; ROS; TLR4; FDA; O2; COX-2; MRI; CNS; DTX; MDR1; CICI; SNP; BCNU; ApoA1; Chemotherapy-induced cognitive impairment; APOE; GCEE; GSH; ABCA1; PGE2; MRP1; Mitochondrial dysfunction; BDNF; Oxidative damage; STAT3; 8-oxoG; BER; GIGT; NAC; PC; PD; TNF-α; MnSOD; HNE; PET

Increasing numbers of cancer patients survive and live longer than five years after therapy, but very often side effects of cancer treatment arise at same time. One of the side effects, chemotherapy-induced cognitive impairment (CICI), also called “chemobrain” or “chemofog” by patients, brings enorm...