Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction

• Published in: Developmental cell Vol. 51; no. 5; pp. 587 - 601.e7
• Main Authors: Egge, Nathan, Arneaud, Sonja L.B., Wales, Pauline, Mihelakis, Melina, McClendon, Jacob, Fonseca, Rene Solano, Savelle, Charles, Gonzalez, Ian, Ghorashi, Atossa, Yadavalli, Sivaramakrishna, Lehman, William J., Mirzaei, Hamid, Douglas, Peter M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.12.2019
• Subjects: actin; aging; barrier; HSF-1; intestine; junctions; kinase; pathogenesis; phosphorylation; stress; pathogenesis; stress; HSF-1; actin; kinase; intestine; barrier; aging; phosphorylation; junctions

Age-associated decay of intercellular interactions impairs the cells’ capacity to tightly associate within tissues and form a functional barrier. This barrier dysfunction compromises organ physiology and contributes to systemic failure. The actin cytoskeleton represents a key determinant in maintain...