Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction

Age-associated decay of intercellular interactions impairs the cells’ capacity to tightly associate within tissues and form a functional barrier. This barrier dysfunction compromises organ physiology and contributes to systemic failure. The actin cytoskeleton represents a key determinant in maintain...

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Published inDevelopmental cell Vol. 51; no. 5; pp. 587 - 601.e7
Main Authors Egge, Nathan, Arneaud, Sonja L.B., Wales, Pauline, Mihelakis, Melina, McClendon, Jacob, Fonseca, Rene Solano, Savelle, Charles, Gonzalez, Ian, Ghorashi, Atossa, Yadavalli, Sivaramakrishna, Lehman, William J., Mirzaei, Hamid, Douglas, Peter M.
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LanguageEnglish
Published United States Elsevier Inc 02.12.2019
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Abstract Age-associated decay of intercellular interactions impairs the cells’ capacity to tightly associate within tissues and form a functional barrier. This barrier dysfunction compromises organ physiology and contributes to systemic failure. The actin cytoskeleton represents a key determinant in maintaining tissue architecture. Yet, it is unclear how age disrupts the actin cytoskeleton and how this, in turn, promotes mortality. Here, we show that an uncharacterized phosphorylation of a low-abundant actin variant, ACT-5, compromises integrity of the C. elegans intestinal barrier and accelerates pathogenesis. Age-related loss of the heat-shock transcription factor, HSF-1, disrupts the JUN kinase and protein phosphatase I equilibrium which increases ACT-5 phosphorylation within its troponin binding site. Phosphorylated ACT-5 accelerates decay of the intestinal subapical terminal web and impairs its interactions with cell junctions. This compromises barrier integrity, promotes pathogenesis, and drives mortality. Thus, we provide the molecular mechanism by which age-associated loss of specialized actin networks impacts tissue integrity. [Display omitted] •The low-abundant, intestine-specific actin (ACT-5) affects animal aging•ACT-5 phosphorylation within its troponin binding site destabilizes actin networks•The Jun kinase (KGB-1) and PP1 phosphatase (GSP-1) regulate ACT-5 phosphorylation•Repression of KGB-1 by HSF-1 impacts the intestinal barrier and pathogenesis Aging is accompanied by a general loss of organ integrity. In the intestine, this “leakiness” can lead to infection, inflammation, and disease. Herein, Egge et al. uncover how dysregulation of a major structural component of cells, actin, leads to the loss of the intestine’s barrier and drives age and mortality.
AbstractList Age-associated decay of intercellular interactions impairs the cells’ capacity to tightly associate within tissues and form a functional barrier. This barrier dysfunction compromises organ physiology and contributes to systemic failure. The actin cytoskeleton represents a key determinant in maintaining tissue architecture. Yet it is unclear how age disrupts the actin cytoskeleton, and how this, in turn, promotes mortality. Here we show that an uncharacterized phosphorylation of a low-abundant actin variant, ACT-5, compromises integrity of the C. elegans intestinal barrier and accelerates pathogenesis. Age-related loss of the heat shock transcription factor, HSF-1, disrupts the JUN kinase/Protein Phosphatase I equilibrium and increases ACT-5 phosphorylation within its troponin-binding site. Phosphorylated ACT-5 accelerates decay of the intestinal sub-apical terminal web and impairs its interactions with cell junctions. This compromises barrier integrity, promotes pathogenesis, and drives mortality. Thus, we provide the molecular mechanism by which age-associated loss of specialized actin networks impacts tissue integrity. Aging is accompanied by a general loss of organ integrity. In the intestine, this “leakiness” can lead to infection, inflammation, and disease. Herein, Egge et al. uncover how dysregulation of a major structural component of cells, actin, leads to the loss of the intestine’s barrier and drives age and mortality.
Age-associated decay of intercellular interactions impairs the cells' capacity to tightly associate within tissues and form a functional barrier. This barrier dysfunction compromises organ physiology and contributes to systemic failure. The actin cytoskeleton represents a key determinant in maintaining tissue architecture. Yet, it is unclear how age disrupts the actin cytoskeleton and how this, in turn, promotes mortality. Here, we show that an uncharacterized phosphorylation of a low-abundant actin variant, ACT-5, compromises integrity of the C. elegans intestinal barrier and accelerates pathogenesis. Age-related loss of the heat-shock transcription factor, HSF-1, disrupts the JUN kinase and protein phosphatase I equilibrium which increases ACT-5 phosphorylation within its troponin binding site. Phosphorylated ACT-5 accelerates decay of the intestinal subapical terminal web and impairs its interactions with cell junctions. This compromises barrier integrity, promotes pathogenesis, and drives mortality. Thus, we provide the molecular mechanism by which age-associated loss of specialized actin networks impacts tissue integrity.
Age-associated decay of intercellular interactions impairs the cells’ capacity to tightly associate within tissues and form a functional barrier. This barrier dysfunction compromises organ physiology and contributes to systemic failure. The actin cytoskeleton represents a key determinant in maintaining tissue architecture. Yet, it is unclear how age disrupts the actin cytoskeleton and how this, in turn, promotes mortality. Here, we show that an uncharacterized phosphorylation of a low-abundant actin variant, ACT-5, compromises integrity of the C. elegans intestinal barrier and accelerates pathogenesis. Age-related loss of the heat-shock transcription factor, HSF-1, disrupts the JUN kinase and protein phosphatase I equilibrium which increases ACT-5 phosphorylation within its troponin binding site. Phosphorylated ACT-5 accelerates decay of the intestinal subapical terminal web and impairs its interactions with cell junctions. This compromises barrier integrity, promotes pathogenesis, and drives mortality. Thus, we provide the molecular mechanism by which age-associated loss of specialized actin networks impacts tissue integrity. [Display omitted] •The low-abundant, intestine-specific actin (ACT-5) affects animal aging•ACT-5 phosphorylation within its troponin binding site destabilizes actin networks•The Jun kinase (KGB-1) and PP1 phosphatase (GSP-1) regulate ACT-5 phosphorylation•Repression of KGB-1 by HSF-1 impacts the intestinal barrier and pathogenesis Aging is accompanied by a general loss of organ integrity. In the intestine, this “leakiness” can lead to infection, inflammation, and disease. Herein, Egge et al. uncover how dysregulation of a major structural component of cells, actin, leads to the loss of the intestine’s barrier and drives age and mortality.
Author Gonzalez, Ian
Douglas, Peter M.
McClendon, Jacob
Fonseca, Rene Solano
Wales, Pauline
Arneaud, Sonja L.B.
Yadavalli, Sivaramakrishna
Lehman, William J.
Mirzaei, Hamid
Savelle, Charles
Ghorashi, Atossa
Egge, Nathan
Mihelakis, Melina
AuthorAffiliation 1 Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
2 Medical Scientist Training Program, UT Southwestern Medical Center, Dallas, TX 75390, USA
6 Lead Contact
3 Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA
4 Department of Structural Biology, Boston University, Boston, MA 02118, USA
5 Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA
AuthorAffiliation_xml – name: 1 Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA
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Cites_doi 10.1126/science.2166336
10.1111/j.1474-9726.2012.00829.x
10.1186/1477-5956-9-S1-S6
10.1083/jcb.111.3.1081
10.1083/jcb.141.1.297
10.1038/ncb3454
10.1126/science.1253168
10.1038/nature14033
10.1016/0022-2836(83)90056-6
10.7554/eLife.04872
10.1038/sj.emboj.7600226
10.1126/science.aan0814
10.1126/science.aar3318
10.1126/science.1072161
10.1126/science.7678470
10.1016/j.ceb.2012.10.009
10.1016/j.cellsig.2016.11.010
10.1016/j.devcel.2004.05.018
10.1038/nrm2938
10.1016/0378-1119(93)90290-J
10.1042/BJ20140450
10.1016/S0891-5849(03)00328-9
10.1371/journal.pgen.1003315
10.1007/978-94-007-4186-7_12
10.1186/s12864-016-2837-5
10.1080/21688370.2017.1343172
10.1126/science.1083701
10.1016/j.devcel.2018.10.025
10.1111/cmi.12481
10.1242/jcs.114.12.2265
10.1023/A:1018785127079
10.1091/mbc.12.11.3465
10.1016/S0006-3495(03)70041-1
10.1038/srep23523
10.1021/pr801109k
10.1091/mbc.E18-06-0362
10.1016/0022-2836(84)90023-8
10.1073/pnas.0606321103
10.1091/mbc.e10-10-0862
10.1101/gr.2505604
10.1016/S0960-9822(00)00859-9
10.1016/j.celrep.2015.07.026
10.1016/j.molcel.2015.06.027
10.1111/j.1474-9726.2011.00713.x
10.1126/science.aar7201
10.1093/nar/9.19.4895
10.1038/ncb3335
10.1016/j.bbamem.2007.07.012
10.1038/nmeth1113
10.1242/jcs.215509
10.1073/pnas.0902882106
10.1016/j.jmb.2008.04.062
10.1073/pnas.1215849110
10.1073/pnas.81.15.4889
10.1016/0022-2836(84)90024-X
10.1093/genetics/161.3.1101
10.1091/mbc.e04-12-1061
10.1016/j.bpj.2014.01.007
10.1016/j.stem.2008.07.024
10.1093/genetics/77.1.71
10.1073/pnas.94.9.4406
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Issue 5
Keywords pathogenesis
stress
HSF-1
actin
kinase
intestine
barrier
aging
phosphorylation
junctions
Language English
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Equal contribution from authors
AUTHOR CONTRIBUTIONS
Conceptualization: N.E., P.W., P.M.D; Methodology: N.E., S.L.B.A., P.W., M.M., J.M., C.S., I.G., A.G., S.Y., W.J.L, H.M., P.M.D; Investigation: N.E., S.L.B.A., P.W., M.M., R.S.F., J.M., C.S., I.G.; Writing, Review & Edit: P.M.D, N.E., S.L.B.A., W.J.L; Funding acquisition, Resources, & Supervision: P.M.D., H.M, W.J.L.
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References Furuhashi, Hatano (bib16) 1990; 111
Ben-Zvi, Miller, Morimoto (bib5) 2009; 106
Galińska-Rakoczy, Engel, Xu, Jung, Craig, Tobacman, Lehman (bib18) 2008; 379
Baird, Douglas, Simic, Grant, Moresco, Wolff, Yates, Manning, Dillin (bib4) 2014; 346
Armenti, Nance (bib2) 2012; 60
Labbadia, Morimoto (bib32) 2015; 59
Käll, Canterbury, Weston, Noble, MacCoss (bib29) 2007; 4
Rual, Ceron, Koreth, Hao, Nicot, Hirozane-Kishikawa, Vandenhaute, Orkin, Hill, van den Heuvel (bib44) 2004; 14
Hartsock, Nelson (bib23) 2008; 1778
Zhang, Liu, Twumasi-Boateng, Block, Shapira (bib61) 2017; 30
Resnik-Docampo, Koehler, Clark, Schinaman, Sauer, Wong, Lewis, D'Alterio, Walker, Jones (bib43) 2017; 19
Files, Carr, Hirsh (bib14) 1983; 164
Sumi, Hayes, D'Angelo, Colombelli, Salbreux, Dierkes, Solon (bib52) 2018; 47
Guan, Dixon (bib22) 1990; 249
Brenner (bib8) 1974; 77
Ayscough (bib3) 2000; 10
Samak, Chaudhry, Gangwar, Narayanan, Jaggar, Rao (bib46) 2015; 465
Waterston, Hirsh, Lane (bib59) 1984; 180
Brunquell, Morris, Lu, Cheng, Westerheide (bib9) 2016; 17
Howard, Sefton, Firtel (bib26) 1993; 259
Chambers, Dalton, Clarke, Malzer, Dominicus, Patel, Moorhead, Ron, Marciniak (bib10) 2015; 4
Firestein, Rongo (bib15) 2001; 12
Knust, Bossinger (bib30) 2002; 298
Su, Cao, Tang, Dai, He, Sampson, Benjamin, Dai (bib51) 2016; 18
McGee, Weber, Day, Vitelli, Crippen, Herndon, Hall, Melov (bib37) 2011; 10
Garigan, Hsu, Fraser, Kamath, Ahringer, Kenyon (bib19) 2002; 161
Landel, Krause, Waterston, Hirsh (bib33) 1984; 180
Higuchi-Sanabria, Paul, Durieux, Benitez, Frankino, Tronnes, Garcia, Daniele, Monshietehadi, Dillin (bib25) 2018; 29
Biteau, Hochmuth, Jasper (bib7) 2008; 3
Mizuno, Hisamoto, Terada, Kondo, Adachi, Nishida, Kim, Ausubel, Matsumoto (bib39) 2004; 23
MacQueen, Baggett, Perumov, Bauer, Januszewski, Schriefer, Waddle (bib35) 2005; 16
Hsu, Murphy, Kenyon (bib27) 2003; 300
Rera, Clark, Walker (bib42) 2012; 109
Hattori, Mizuno, Akamatsu, Hisamoto, Matsumoto (bib24) 2013; 9
Mohanan, Nakata, Desch, Lévesque, Boroughs, Guzman, Cao, Creasey, Yao, Boucher (bib40) 2018; 359
Liu, Shu, Hong, Levine, Korn (bib34) 2006; 103
Humphries, Whittall, Minty, Buckingham, Williamson (bib28) 1981; 9
Stone, Shaw (bib50) 1993; 131
Douglas, Baird, Simic, Uhlein, McCormick, Wolff, Kennedy, Dillin (bib13) 2015; 12
Szumowski, Estes, Popovich, Botts, Sek, Troemel (bib53) 2016; 18
Kumar, Crawford, Close, Madison, Lorenz, Doetschman, Pawlowski, Duffy, Neumann, Robbins (bib31) 1997; 94
McMahon, Legouis, Vonesch, Labouesse (bib38) 2001; 114
Terman, Kashina (bib54) 2013; 25
Shortle, Novick, Botstein (bib47) 1984; 81
Smith, Geeves (bib48) 2003; 84
Dambroise, Monnier, Ruisheng, Aguilaniu, Joly, Tricoire, Rera (bib12) 2016; 6
Gill, Olsen, Sampayo, Lithgow (bib20) 2003; 35
Akerfelt, Morimoto, Sistonen (bib1) 2010; 11
Safaei, Maňuch, Gupta, Stacho, Pelech (bib45) 2011; 9
Manfredo Vieira, Hiltensperger, Kumar, Zegarra-Ruiz, Dehner, Khan, Costa, Tiniakou, Greiling, Ruff (bib36) 2018; 359
Bernadskaya, Patel, Hsu, Soto (bib6) 2011; 22
Twumasi-Boateng, Wang, Tsai, Lee, Salehpour, Bhat, Tan, Shapira (bib56) 2012; 11
Costa, Raich, Agbunag, Leung, Hardin, Priess (bib11) 1998; 141
von der Ecken, Müller, Lehman, Manstein, Penczek, Raunser (bib58) 2015; 519
Yang, Barbu-Tudoran, Orzechowski, Craig, Trinick, White, Lehman (bib60) 2014; 106
Parrish (bib41) 2017; 5
Vedula, Kashina (bib57) 2018; 131
Fyrberg, Fyrberg, Biggs, Saville, Beall, Ketchum (bib17) 1998; 36
Göbel, Barrett, Hall, Fleming (bib21) 2004; 6
Spivak, Weston, Bottou, Käll, Noble (bib49) 2009; 8
Thaiss, Levy, Grosheva, Zheng, Soffer, Blacher, Braverman, Tengeler, Barak, Elazar (bib55) 2018; 359
Howard (10.1016/j.devcel.2019.11.001_bib26) 1993; 259
Ayscough (10.1016/j.devcel.2019.11.001_bib3) 2000; 10
Chambers (10.1016/j.devcel.2019.11.001_bib10) 2015; 4
Mohanan (10.1016/j.devcel.2019.11.001_bib40) 2018; 359
McMahon (10.1016/j.devcel.2019.11.001_bib38) 2001; 114
Humphries (10.1016/j.devcel.2019.11.001_bib28) 1981; 9
Brunquell (10.1016/j.devcel.2019.11.001_bib9) 2016; 17
Smith (10.1016/j.devcel.2019.11.001_bib48) 2003; 84
Baird (10.1016/j.devcel.2019.11.001_bib4) 2014; 346
Mizuno (10.1016/j.devcel.2019.11.001_bib39) 2004; 23
Resnik-Docampo (10.1016/j.devcel.2019.11.001_bib43) 2017; 19
Rual (10.1016/j.devcel.2019.11.001_bib44) 2004; 14
Yang (10.1016/j.devcel.2019.11.001_bib60) 2014; 106
Thaiss (10.1016/j.devcel.2019.11.001_bib55) 2018; 359
Waterston (10.1016/j.devcel.2019.11.001_bib59) 1984; 180
Knust (10.1016/j.devcel.2019.11.001_bib30) 2002; 298
Brenner (10.1016/j.devcel.2019.11.001_bib8) 1974; 77
Vedula (10.1016/j.devcel.2019.11.001_bib57) 2018; 131
Zhang (10.1016/j.devcel.2019.11.001_bib61) 2017; 30
Firestein (10.1016/j.devcel.2019.11.001_bib15) 2001; 12
Landel (10.1016/j.devcel.2019.11.001_bib33) 1984; 180
Akerfelt (10.1016/j.devcel.2019.11.001_bib1) 2010; 11
Hattori (10.1016/j.devcel.2019.11.001_bib24) 2013; 9
Hartsock (10.1016/j.devcel.2019.11.001_bib23) 2008; 1778
Su (10.1016/j.devcel.2019.11.001_bib51) 2016; 18
Bernadskaya (10.1016/j.devcel.2019.11.001_bib6) 2011; 22
Fyrberg (10.1016/j.devcel.2019.11.001_bib17) 1998; 36
Göbel (10.1016/j.devcel.2019.11.001_bib21) 2004; 6
Files (10.1016/j.devcel.2019.11.001_bib14) 1983; 164
Stone (10.1016/j.devcel.2019.11.001_bib50) 1993; 131
Sumi (10.1016/j.devcel.2019.11.001_bib52) 2018; 47
Liu (10.1016/j.devcel.2019.11.001_bib34) 2006; 103
Shortle (10.1016/j.devcel.2019.11.001_bib47) 1984; 81
Hsu (10.1016/j.devcel.2019.11.001_bib27) 2003; 300
Twumasi-Boateng (10.1016/j.devcel.2019.11.001_bib56) 2012; 11
Furuhashi (10.1016/j.devcel.2019.11.001_bib16) 1990; 111
Szumowski (10.1016/j.devcel.2019.11.001_bib53) 2016; 18
Labbadia (10.1016/j.devcel.2019.11.001_bib32) 2015; 59
Rera (10.1016/j.devcel.2019.11.001_bib42) 2012; 109
Safaei (10.1016/j.devcel.2019.11.001_bib45) 2011; 9
Armenti (10.1016/j.devcel.2019.11.001_bib2) 2012; 60
von der Ecken (10.1016/j.devcel.2019.11.001_bib58) 2015; 519
Kumar (10.1016/j.devcel.2019.11.001_bib31) 1997; 94
Spivak (10.1016/j.devcel.2019.11.001_bib49) 2009; 8
Galińska-Rakoczy (10.1016/j.devcel.2019.11.001_bib18) 2008; 379
Gill (10.1016/j.devcel.2019.11.001_bib20) 2003; 35
Costa (10.1016/j.devcel.2019.11.001_bib11) 1998; 141
Ben-Zvi (10.1016/j.devcel.2019.11.001_bib5) 2009; 106
MacQueen (10.1016/j.devcel.2019.11.001_bib35) 2005; 16
Parrish (10.1016/j.devcel.2019.11.001_bib41) 2017; 5
Biteau (10.1016/j.devcel.2019.11.001_bib7) 2008; 3
McGee (10.1016/j.devcel.2019.11.001_bib37) 2011; 10
Dambroise (10.1016/j.devcel.2019.11.001_bib12) 2016; 6
Douglas (10.1016/j.devcel.2019.11.001_bib13) 2015; 12
Käll (10.1016/j.devcel.2019.11.001_bib29) 2007; 4
Garigan (10.1016/j.devcel.2019.11.001_bib19) 2002; 161
Guan (10.1016/j.devcel.2019.11.001_bib22) 1990; 249
Higuchi-Sanabria (10.1016/j.devcel.2019.11.001_bib25) 2018; 29
Samak (10.1016/j.devcel.2019.11.001_bib46) 2015; 465
Manfredo Vieira (10.1016/j.devcel.2019.11.001_bib36) 2018; 359
Terman (10.1016/j.devcel.2019.11.001_bib54) 2013; 25
References_xml – volume: 111
  start-page: 1081
  year: 1990
  end-page: 1087
  ident: bib16
  article-title: Control of actin filament length by phosphorylation of Fragmin-actin complex
  publication-title: J. Cell Biol.
  contributor:
    fullname: Hatano
– volume: 10
  start-page: 699
  year: 2011
  end-page: 710
  ident: bib37
  article-title: Loss of intestinal nuclei and intestinal integrity in aging C. elegans
  publication-title: Aging Cell
  contributor:
    fullname: Melov
– volume: 12
  start-page: 1196
  year: 2015
  end-page: 1204
  ident: bib13
  article-title: Heterotypic signals from neural HSF-1 separate thermotolerance from longevity
  publication-title: Cell Rep.
  contributor:
    fullname: Dillin
– volume: 23
  start-page: 2226
  year: 2004
  end-page: 2234
  ident: bib39
  article-title: The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response
  publication-title: EMBO J.
  contributor:
    fullname: Matsumoto
– volume: 114
  start-page: 2265
  year: 2001
  end-page: 2277
  ident: bib38
  article-title: Assembly of C. elegans apical junctions involves positioning and compaction by LET-413 and protein aggregation by the MAGUK protein DLG-1
  publication-title: J. Cell Sci.
  contributor:
    fullname: Labouesse
– volume: 106
  start-page: 855
  year: 2014
  end-page: 864
  ident: bib60
  article-title: Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state
  publication-title: Biophys. J.
  contributor:
    fullname: Lehman
– volume: 18
  start-page: 527
  year: 2016
  end-page: 539
  ident: bib51
  article-title: HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Dai
– volume: 35
  start-page: 558
  year: 2003
  end-page: 565
  ident: bib20
  article-title: An automated high-throughput assay for survival of the nematode Caenorhabditis elegans
  publication-title: Free Radic. Biol. Med.
  contributor:
    fullname: Lithgow
– volume: 131
  year: 2018
  ident: bib57
  article-title: The makings of the 'actin code': regulation of actin's biological function at the amino acid and nucleotide level
  publication-title: J. Cell Sci.
  contributor:
    fullname: Kashina
– volume: 379
  start-page: 929
  year: 2008
  end-page: 935
  ident: bib18
  article-title: Structural basis for the regulation of muscle contraction by troponin and tropomyosin
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Lehman
– volume: 131
  start-page: 167
  year: 1993
  end-page: 173
  ident: bib50
  article-title: A Caenorhabditis elegans act-4::lacZ fusion: use as a transformation marker and analysis of tissue-specific expression
  publication-title: Gene
  contributor:
    fullname: Shaw
– volume: 465
  start-page: 503
  year: 2015
  end-page: 515
  ident: bib46
  article-title: Calcium/ASK1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium
  publication-title: Biochem. J.
  contributor:
    fullname: Rao
– volume: 10
  start-page: 1587
  year: 2000
  end-page: 1590
  ident: bib3
  article-title: Endocytosis and the development of cell polarity in yeast require a dynamic F-actin cytoskeleton
  publication-title: Curr. Biol.
  contributor:
    fullname: Ayscough
– volume: 300
  start-page: 1142
  year: 2003
  end-page: 1145
  ident: bib27
  article-title: Regulation of aging and age-related disease by DAF-16 and heat-shock factor
  publication-title: Science
  contributor:
    fullname: Kenyon
– volume: 9
  year: 2011
  ident: bib45
  article-title: Prediction of 492 human protein kinase substrate specificities
  publication-title: Proteome Sci.
  contributor:
    fullname: Pelech
– volume: 29
  start-page: 2522
  year: 2018
  end-page: 2527
  ident: bib25
  article-title: Spatial regulation of the actin cytoskeleton by HSF-1 during aging
  publication-title: Mol. Biol. Cell
  contributor:
    fullname: Dillin
– volume: 11
  start-page: 545
  year: 2010
  end-page: 555
  ident: bib1
  article-title: Heat shock factors: integrators of cell stress, development and lifespan
  publication-title: Nat. Rev. Mol. Cell Biol.
  contributor:
    fullname: Sistonen
– volume: 84
  start-page: 3168
  year: 2003
  end-page: 3180
  ident: bib48
  article-title: Cooperative regulation of myosin-actin interactions by a continuous flexible chain II: actin-tropomyosin-troponin and regulation by calcium
  publication-title: Biophys. J.
  contributor:
    fullname: Geeves
– volume: 30
  start-page: 1
  year: 2017
  end-page: 8
  ident: bib61
  article-title: FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1
  publication-title: Cell. Signal.
  contributor:
    fullname: Shapira
– volume: 22
  start-page: 2886
  year: 2011
  end-page: 2899
  ident: bib6
  article-title: Arp2/3 promotes junction formation and maintenance in the Caenorhabditis elegans intestine by regulating membrane association of apical proteins
  publication-title: Mol. Biol. Cell
  contributor:
    fullname: Soto
– volume: 12
  start-page: 3465
  year: 2001
  end-page: 3475
  ident: bib15
  article-title: DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation
  publication-title: Mol. Biol. Cell
  contributor:
    fullname: Rongo
– volume: 106
  start-page: 14914
  year: 2009
  end-page: 14919
  ident: bib5
  article-title: Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Morimoto
– volume: 164
  start-page: 355
  year: 1983
  end-page: 375
  ident: bib14
  article-title: Actin gene family of Caenorhabditis elegans
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Hirsh
– volume: 17
  start-page: 559
  year: 2016
  ident: bib9
  article-title: The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans
  publication-title: BMC Genomics
  contributor:
    fullname: Westerheide
– volume: 4
  year: 2015
  ident: bib10
  article-title: Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation
  publication-title: eLife
  contributor:
    fullname: Marciniak
– volume: 9
  start-page: e1003315
  year: 2013
  ident: bib24
  article-title: The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex
  publication-title: PLoS Genet.
  contributor:
    fullname: Matsumoto
– volume: 180
  start-page: 473
  year: 1984
  end-page: 496
  ident: bib59
  article-title: Dominant mutations affecting muscle structure in Caenorhabditis elegans that map near the actin gene cluster
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Lane
– volume: 36
  start-page: 271
  year: 1998
  end-page: 287
  ident: bib17
  article-title: Functional nonequivalence of Drosophila actin isoforms
  publication-title: Biochem. Genet.
  contributor:
    fullname: Ketchum
– volume: 359
  start-page: 1161
  year: 2018
  end-page: 1166
  ident: bib40
  article-title: C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions
  publication-title: Science
  contributor:
    fullname: Boucher
– volume: 60
  start-page: 279
  year: 2012
  end-page: 299
  ident: bib2
  article-title: Adherens junctions in C. elegans embryonic morphogenesis
  publication-title: Subcell. Biochem.
  contributor:
    fullname: Nance
– volume: 6
  start-page: 23523
  year: 2016
  ident: bib12
  article-title: Two phases of aging separated by the Smurf transition as a public path to death
  publication-title: Sci. Rep.
  contributor:
    fullname: Rera
– volume: 346
  start-page: 360
  year: 2014
  end-page: 363
  ident: bib4
  article-title: HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span
  publication-title: Science
  contributor:
    fullname: Dillin
– volume: 59
  start-page: 639
  year: 2015
  end-page: 650
  ident: bib32
  article-title: Repression of the heat shock response is a programmed event at the onset of reproduction
  publication-title: Mol. Cell
  contributor:
    fullname: Morimoto
– volume: 25
  start-page: 30
  year: 2013
  end-page: 38
  ident: bib54
  article-title: Post-translational modification and regulation of actin
  publication-title: Curr. Opin. Cell Biol.
  contributor:
    fullname: Kashina
– volume: 18
  start-page: 30
  year: 2016
  end-page: 45
  ident: bib53
  article-title: Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells
  publication-title: Cell. Microbiol.
  contributor:
    fullname: Troemel
– volume: 94
  start-page: 4406
  year: 1997
  end-page: 4411
  ident: bib31
  article-title: Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Robbins
– volume: 259
  start-page: 241
  year: 1993
  end-page: 244
  ident: bib26
  article-title: Tyrosine phosphorylation of actin in Dictyostelium associated with cell-shape changes
  publication-title: Science
  contributor:
    fullname: Firtel
– volume: 14
  start-page: 2162
  year: 2004
  end-page: 2168
  ident: bib44
  article-title: Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library
  publication-title: Genome Res.
  contributor:
    fullname: van den Heuvel
– volume: 8
  start-page: 3737
  year: 2009
  end-page: 3745
  ident: bib49
  article-title: Improvements to the percolator algorithm for Peptide identification from shotgun proteomics data sets
  publication-title: J. Proteome Res.
  contributor:
    fullname: Noble
– volume: 161
  start-page: 1101
  year: 2002
  end-page: 1112
  ident: bib19
  article-title: Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
  publication-title: Genetics
  contributor:
    fullname: Kenyon
– volume: 141
  start-page: 297
  year: 1998
  end-page: 308
  ident: bib11
  article-title: A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo
  publication-title: J. Cell Biol.
  contributor:
    fullname: Priess
– volume: 109
  start-page: 21528
  year: 2012
  end-page: 21533
  ident: bib42
  article-title: Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Walker
– volume: 249
  start-page: 553
  year: 1990
  end-page: 556
  ident: bib22
  article-title: Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia
  publication-title: Science
  contributor:
    fullname: Dixon
– volume: 298
  start-page: 1955
  year: 2002
  end-page: 1959
  ident: bib30
  article-title: Composition and formation of intercellular junctions in epithelial cells
  publication-title: Science
  contributor:
    fullname: Bossinger
– volume: 77
  start-page: 71
  year: 1974
  end-page: 94
  ident: bib8
  article-title: The genetics of Caenorhabditis elegans
  publication-title: Genetics
  contributor:
    fullname: Brenner
– volume: 6
  start-page: 865
  year: 2004
  end-page: 873
  ident: bib21
  article-title: Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1
  publication-title: Dev. Cell
  contributor:
    fullname: Fleming
– volume: 359
  start-page: 1156
  year: 2018
  end-page: 1161
  ident: bib36
  article-title: Translocation of a gut pathobiont drives autoimmunity in mice and humans
  publication-title: Science
  contributor:
    fullname: Ruff
– volume: 3
  start-page: 442
  year: 2008
  end-page: 455
  ident: bib7
  article-title: JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
  publication-title: Cell Stem Cell
  contributor:
    fullname: Jasper
– volume: 9
  start-page: 4895
  year: 1981
  end-page: 4908
  ident: bib28
  article-title: There are approximately 20 actin gene in the human genome
  publication-title: Nucleic Acids Res.
  contributor:
    fullname: Williamson
– volume: 359
  start-page: 1376
  year: 2018
  end-page: 1383
  ident: bib55
  article-title: Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection
  publication-title: Science
  contributor:
    fullname: Elazar
– volume: 519
  start-page: 114
  year: 2015
  end-page: 117
  ident: bib58
  article-title: Structure of the F-actin-tropomyosin complex
  publication-title: Nature
  contributor:
    fullname: Raunser
– volume: 81
  start-page: 4889
  year: 1984
  end-page: 4893
  ident: bib47
  article-title: Construction and genetic characterization of temperature-sensitive mutant alleles of the yeast actin gene
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Botstein
– volume: 11
  start-page: 659
  year: 2012
  end-page: 667
  ident: bib56
  article-title: An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan
  publication-title: Aging Cell
  contributor:
    fullname: Shapira
– volume: 4
  start-page: 923
  year: 2007
  end-page: 925
  ident: bib29
  article-title: Semi-supervised learning for peptide identification from shotgun proteomics datasets
  publication-title: Nat. Methods
  contributor:
    fullname: MacCoss
– volume: 1778
  start-page: 660
  year: 2008
  end-page: 669
  ident: bib23
  article-title: Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
  publication-title: Biochim. Biophys. Acta
  contributor:
    fullname: Nelson
– volume: 16
  start-page: 3247
  year: 2005
  end-page: 3259
  ident: bib35
  article-title: ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation
  publication-title: Mol. Biol. Cell
  contributor:
    fullname: Waddle
– volume: 180
  start-page: 497
  year: 1984
  end-page: 513
  ident: bib33
  article-title: DNA rearrangements of the actin gene cluster in Caenorhabditis elegans accompany reversion of three muscle mutants
  publication-title: J. Mol. Biol.
  contributor:
    fullname: Hirsh
– volume: 19
  start-page: 52
  year: 2017
  end-page: 59
  ident: bib43
  article-title: Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis
  publication-title: Nat. Cell Biol.
  contributor:
    fullname: Jones
– volume: 47
  start-page: 453
  year: 2018
  end-page: 463.e3
  ident: bib52
  article-title: Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling
  publication-title: Dev. Cell
  contributor:
    fullname: Solon
– volume: 5
  start-page: e1343172
  year: 2017
  ident: bib41
  article-title: The impact of aging on epithelial barriers
  publication-title: Tissue Barriers
  contributor:
    fullname: Parrish
– volume: 103
  start-page: 13694
  year: 2006
  end-page: 13699
  ident: bib34
  article-title: Phosphorylation of actin Tyr-53 inhibits filament nucleation and elongation and destabilizes filaments
  publication-title: Proc. Natl. Acad. Sci. USA
  contributor:
    fullname: Korn
– volume: 249
  start-page: 553
  year: 1990
  ident: 10.1016/j.devcel.2019.11.001_bib22
  article-title: Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia
  publication-title: Science
  doi: 10.1126/science.2166336
  contributor:
    fullname: Guan
– volume: 11
  start-page: 659
  year: 2012
  ident: 10.1016/j.devcel.2019.11.001_bib56
  article-title: An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2012.00829.x
  contributor:
    fullname: Twumasi-Boateng
– volume: 9
  year: 2011
  ident: 10.1016/j.devcel.2019.11.001_bib45
  article-title: Prediction of 492 human protein kinase substrate specificities
  publication-title: Proteome Sci.
  doi: 10.1186/1477-5956-9-S1-S6
  contributor:
    fullname: Safaei
– volume: 111
  start-page: 1081
  year: 1990
  ident: 10.1016/j.devcel.2019.11.001_bib16
  article-title: Control of actin filament length by phosphorylation of Fragmin-actin complex
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.111.3.1081
  contributor:
    fullname: Furuhashi
– volume: 141
  start-page: 297
  year: 1998
  ident: 10.1016/j.devcel.2019.11.001_bib11
  article-title: A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.141.1.297
  contributor:
    fullname: Costa
– volume: 19
  start-page: 52
  year: 2017
  ident: 10.1016/j.devcel.2019.11.001_bib43
  article-title: Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3454
  contributor:
    fullname: Resnik-Docampo
– volume: 346
  start-page: 360
  year: 2014
  ident: 10.1016/j.devcel.2019.11.001_bib4
  article-title: HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span
  publication-title: Science
  doi: 10.1126/science.1253168
  contributor:
    fullname: Baird
– volume: 519
  start-page: 114
  year: 2015
  ident: 10.1016/j.devcel.2019.11.001_bib58
  article-title: Structure of the F-actin-tropomyosin complex
  publication-title: Nature
  doi: 10.1038/nature14033
  contributor:
    fullname: von der Ecken
– volume: 164
  start-page: 355
  year: 1983
  ident: 10.1016/j.devcel.2019.11.001_bib14
  article-title: Actin gene family of Caenorhabditis elegans
  publication-title: J. Mol. Biol.
  doi: 10.1016/0022-2836(83)90056-6
  contributor:
    fullname: Files
– volume: 4
  year: 2015
  ident: 10.1016/j.devcel.2019.11.001_bib10
  article-title: Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation
  publication-title: eLife
  doi: 10.7554/eLife.04872
  contributor:
    fullname: Chambers
– volume: 23
  start-page: 2226
  year: 2004
  ident: 10.1016/j.devcel.2019.11.001_bib39
  article-title: The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600226
  contributor:
    fullname: Mizuno
– volume: 359
  start-page: 1161
  year: 2018
  ident: 10.1016/j.devcel.2019.11.001_bib40
  article-title: C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions
  publication-title: Science
  doi: 10.1126/science.aan0814
  contributor:
    fullname: Mohanan
– volume: 359
  start-page: 1376
  year: 2018
  ident: 10.1016/j.devcel.2019.11.001_bib55
  article-title: Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection
  publication-title: Science
  doi: 10.1126/science.aar3318
  contributor:
    fullname: Thaiss
– volume: 298
  start-page: 1955
  year: 2002
  ident: 10.1016/j.devcel.2019.11.001_bib30
  article-title: Composition and formation of intercellular junctions in epithelial cells
  publication-title: Science
  doi: 10.1126/science.1072161
  contributor:
    fullname: Knust
– volume: 259
  start-page: 241
  year: 1993
  ident: 10.1016/j.devcel.2019.11.001_bib26
  article-title: Tyrosine phosphorylation of actin in Dictyostelium associated with cell-shape changes
  publication-title: Science
  doi: 10.1126/science.7678470
  contributor:
    fullname: Howard
– volume: 25
  start-page: 30
  year: 2013
  ident: 10.1016/j.devcel.2019.11.001_bib54
  article-title: Post-translational modification and regulation of actin
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2012.10.009
  contributor:
    fullname: Terman
– volume: 30
  start-page: 1
  year: 2017
  ident: 10.1016/j.devcel.2019.11.001_bib61
  article-title: FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2016.11.010
  contributor:
    fullname: Zhang
– volume: 6
  start-page: 865
  year: 2004
  ident: 10.1016/j.devcel.2019.11.001_bib21
  article-title: Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2004.05.018
  contributor:
    fullname: Göbel
– volume: 11
  start-page: 545
  year: 2010
  ident: 10.1016/j.devcel.2019.11.001_bib1
  article-title: Heat shock factors: integrators of cell stress, development and lifespan
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2938
  contributor:
    fullname: Akerfelt
– volume: 131
  start-page: 167
  year: 1993
  ident: 10.1016/j.devcel.2019.11.001_bib50
  article-title: A Caenorhabditis elegans act-4::lacZ fusion: use as a transformation marker and analysis of tissue-specific expression
  publication-title: Gene
  doi: 10.1016/0378-1119(93)90290-J
  contributor:
    fullname: Stone
– volume: 465
  start-page: 503
  year: 2015
  ident: 10.1016/j.devcel.2019.11.001_bib46
  article-title: Calcium/ASK1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium
  publication-title: Biochem. J.
  doi: 10.1042/BJ20140450
  contributor:
    fullname: Samak
– volume: 35
  start-page: 558
  year: 2003
  ident: 10.1016/j.devcel.2019.11.001_bib20
  article-title: An automated high-throughput assay for survival of the nematode Caenorhabditis elegans
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/S0891-5849(03)00328-9
  contributor:
    fullname: Gill
– volume: 9
  start-page: e1003315
  year: 2013
  ident: 10.1016/j.devcel.2019.11.001_bib24
  article-title: The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1003315
  contributor:
    fullname: Hattori
– volume: 60
  start-page: 279
  year: 2012
  ident: 10.1016/j.devcel.2019.11.001_bib2
  article-title: Adherens junctions in C. elegans embryonic morphogenesis
  publication-title: Subcell. Biochem.
  doi: 10.1007/978-94-007-4186-7_12
  contributor:
    fullname: Armenti
– volume: 17
  start-page: 559
  year: 2016
  ident: 10.1016/j.devcel.2019.11.001_bib9
  article-title: The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans
  publication-title: BMC Genomics
  doi: 10.1186/s12864-016-2837-5
  contributor:
    fullname: Brunquell
– volume: 5
  start-page: e1343172
  year: 2017
  ident: 10.1016/j.devcel.2019.11.001_bib41
  article-title: The impact of aging on epithelial barriers
  publication-title: Tissue Barriers
  doi: 10.1080/21688370.2017.1343172
  contributor:
    fullname: Parrish
– volume: 300
  start-page: 1142
  year: 2003
  ident: 10.1016/j.devcel.2019.11.001_bib27
  article-title: Regulation of aging and age-related disease by DAF-16 and heat-shock factor
  publication-title: Science
  doi: 10.1126/science.1083701
  contributor:
    fullname: Hsu
– volume: 47
  start-page: 453
  year: 2018
  ident: 10.1016/j.devcel.2019.11.001_bib52
  article-title: Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2018.10.025
  contributor:
    fullname: Sumi
– volume: 18
  start-page: 30
  year: 2016
  ident: 10.1016/j.devcel.2019.11.001_bib53
  article-title: Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells
  publication-title: Cell. Microbiol.
  doi: 10.1111/cmi.12481
  contributor:
    fullname: Szumowski
– volume: 114
  start-page: 2265
  year: 2001
  ident: 10.1016/j.devcel.2019.11.001_bib38
  article-title: Assembly of C. elegans apical junctions involves positioning and compaction by LET-413 and protein aggregation by the MAGUK protein DLG-1
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.114.12.2265
  contributor:
    fullname: McMahon
– volume: 36
  start-page: 271
  year: 1998
  ident: 10.1016/j.devcel.2019.11.001_bib17
  article-title: Functional nonequivalence of Drosophila actin isoforms
  publication-title: Biochem. Genet.
  doi: 10.1023/A:1018785127079
  contributor:
    fullname: Fyrberg
– volume: 12
  start-page: 3465
  year: 2001
  ident: 10.1016/j.devcel.2019.11.001_bib15
  article-title: DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.12.11.3465
  contributor:
    fullname: Firestein
– volume: 84
  start-page: 3168
  year: 2003
  ident: 10.1016/j.devcel.2019.11.001_bib48
  article-title: Cooperative regulation of myosin-actin interactions by a continuous flexible chain II: actin-tropomyosin-troponin and regulation by calcium
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(03)70041-1
  contributor:
    fullname: Smith
– volume: 6
  start-page: 23523
  year: 2016
  ident: 10.1016/j.devcel.2019.11.001_bib12
  article-title: Two phases of aging separated by the Smurf transition as a public path to death
  publication-title: Sci. Rep.
  doi: 10.1038/srep23523
  contributor:
    fullname: Dambroise
– volume: 8
  start-page: 3737
  year: 2009
  ident: 10.1016/j.devcel.2019.11.001_bib49
  article-title: Improvements to the percolator algorithm for Peptide identification from shotgun proteomics data sets
  publication-title: J. Proteome Res.
  doi: 10.1021/pr801109k
  contributor:
    fullname: Spivak
– volume: 29
  start-page: 2522
  year: 2018
  ident: 10.1016/j.devcel.2019.11.001_bib25
  article-title: Spatial regulation of the actin cytoskeleton by HSF-1 during aging
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E18-06-0362
  contributor:
    fullname: Higuchi-Sanabria
– volume: 180
  start-page: 473
  year: 1984
  ident: 10.1016/j.devcel.2019.11.001_bib59
  article-title: Dominant mutations affecting muscle structure in Caenorhabditis elegans that map near the actin gene cluster
  publication-title: J. Mol. Biol.
  doi: 10.1016/0022-2836(84)90023-8
  contributor:
    fullname: Waterston
– volume: 103
  start-page: 13694
  year: 2006
  ident: 10.1016/j.devcel.2019.11.001_bib34
  article-title: Phosphorylation of actin Tyr-53 inhibits filament nucleation and elongation and destabilizes filaments
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0606321103
  contributor:
    fullname: Liu
– volume: 22
  start-page: 2886
  year: 2011
  ident: 10.1016/j.devcel.2019.11.001_bib6
  article-title: Arp2/3 promotes junction formation and maintenance in the Caenorhabditis elegans intestine by regulating membrane association of apical proteins
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e10-10-0862
  contributor:
    fullname: Bernadskaya
– volume: 14
  start-page: 2162
  year: 2004
  ident: 10.1016/j.devcel.2019.11.001_bib44
  article-title: Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library
  publication-title: Genome Res.
  doi: 10.1101/gr.2505604
  contributor:
    fullname: Rual
– volume: 10
  start-page: 1587
  year: 2000
  ident: 10.1016/j.devcel.2019.11.001_bib3
  article-title: Endocytosis and the development of cell polarity in yeast require a dynamic F-actin cytoskeleton
  publication-title: Curr. Biol.
  doi: 10.1016/S0960-9822(00)00859-9
  contributor:
    fullname: Ayscough
– volume: 12
  start-page: 1196
  year: 2015
  ident: 10.1016/j.devcel.2019.11.001_bib13
  article-title: Heterotypic signals from neural HSF-1 separate thermotolerance from longevity
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.07.026
  contributor:
    fullname: Douglas
– volume: 59
  start-page: 639
  year: 2015
  ident: 10.1016/j.devcel.2019.11.001_bib32
  article-title: Repression of the heat shock response is a programmed event at the onset of reproduction
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2015.06.027
  contributor:
    fullname: Labbadia
– volume: 10
  start-page: 699
  year: 2011
  ident: 10.1016/j.devcel.2019.11.001_bib37
  article-title: Loss of intestinal nuclei and intestinal integrity in aging C. elegans
  publication-title: Aging Cell
  doi: 10.1111/j.1474-9726.2011.00713.x
  contributor:
    fullname: McGee
– volume: 359
  start-page: 1156
  year: 2018
  ident: 10.1016/j.devcel.2019.11.001_bib36
  article-title: Translocation of a gut pathobiont drives autoimmunity in mice and humans
  publication-title: Science
  doi: 10.1126/science.aar7201
  contributor:
    fullname: Manfredo Vieira
– volume: 9
  start-page: 4895
  year: 1981
  ident: 10.1016/j.devcel.2019.11.001_bib28
  article-title: There are approximately 20 actin gene in the human genome
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/9.19.4895
  contributor:
    fullname: Humphries
– volume: 18
  start-page: 527
  year: 2016
  ident: 10.1016/j.devcel.2019.11.001_bib51
  article-title: HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3335
  contributor:
    fullname: Su
– volume: 1778
  start-page: 660
  year: 2008
  ident: 10.1016/j.devcel.2019.11.001_bib23
  article-title: Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamem.2007.07.012
  contributor:
    fullname: Hartsock
– volume: 4
  start-page: 923
  year: 2007
  ident: 10.1016/j.devcel.2019.11.001_bib29
  article-title: Semi-supervised learning for peptide identification from shotgun proteomics datasets
  publication-title: Nat. Methods
  doi: 10.1038/nmeth1113
  contributor:
    fullname: Käll
– volume: 131
  year: 2018
  ident: 10.1016/j.devcel.2019.11.001_bib57
  article-title: The makings of the 'actin code': regulation of actin's biological function at the amino acid and nucleotide level
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.215509
  contributor:
    fullname: Vedula
– volume: 106
  start-page: 14914
  year: 2009
  ident: 10.1016/j.devcel.2019.11.001_bib5
  article-title: Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0902882106
  contributor:
    fullname: Ben-Zvi
– volume: 379
  start-page: 929
  year: 2008
  ident: 10.1016/j.devcel.2019.11.001_bib18
  article-title: Structural basis for the regulation of muscle contraction by troponin and tropomyosin
  publication-title: J. Mol. Biol.
  doi: 10.1016/j.jmb.2008.04.062
  contributor:
    fullname: Galińska-Rakoczy
– volume: 109
  start-page: 21528
  year: 2012
  ident: 10.1016/j.devcel.2019.11.001_bib42
  article-title: Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1215849110
  contributor:
    fullname: Rera
– volume: 81
  start-page: 4889
  year: 1984
  ident: 10.1016/j.devcel.2019.11.001_bib47
  article-title: Construction and genetic characterization of temperature-sensitive mutant alleles of the yeast actin gene
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.81.15.4889
  contributor:
    fullname: Shortle
– volume: 180
  start-page: 497
  year: 1984
  ident: 10.1016/j.devcel.2019.11.001_bib33
  article-title: DNA rearrangements of the actin gene cluster in Caenorhabditis elegans accompany reversion of three muscle mutants
  publication-title: J. Mol. Biol.
  doi: 10.1016/0022-2836(84)90024-X
  contributor:
    fullname: Landel
– volume: 161
  start-page: 1101
  year: 2002
  ident: 10.1016/j.devcel.2019.11.001_bib19
  article-title: Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation
  publication-title: Genetics
  doi: 10.1093/genetics/161.3.1101
  contributor:
    fullname: Garigan
– volume: 16
  start-page: 3247
  year: 2005
  ident: 10.1016/j.devcel.2019.11.001_bib35
  article-title: ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e04-12-1061
  contributor:
    fullname: MacQueen
– volume: 106
  start-page: 855
  year: 2014
  ident: 10.1016/j.devcel.2019.11.001_bib60
  article-title: Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2014.01.007
  contributor:
    fullname: Yang
– volume: 3
  start-page: 442
  year: 2008
  ident: 10.1016/j.devcel.2019.11.001_bib7
  article-title: JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.07.024
  contributor:
    fullname: Biteau
– volume: 77
  start-page: 71
  year: 1974
  ident: 10.1016/j.devcel.2019.11.001_bib8
  article-title: The genetics of Caenorhabditis elegans
  publication-title: Genetics
  doi: 10.1093/genetics/77.1.71
  contributor:
    fullname: Brenner
– volume: 94
  start-page: 4406
  year: 1997
  ident: 10.1016/j.devcel.2019.11.001_bib31
  article-title: Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.94.9.4406
  contributor:
    fullname: Kumar
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Snippet Age-associated decay of intercellular interactions impairs the cells’ capacity to tightly associate within tissues and form a functional barrier. This barrier...
Age-associated decay of intercellular interactions impairs the cells' capacity to tightly associate within tissues and form a functional barrier. This barrier...
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SubjectTerms actin
aging
barrier
HSF-1
intestine
junctions
kinase
pathogenesis
phosphorylation
stress
Title Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction
URI https://dx.doi.org/10.1016/j.devcel.2019.11.001
https://www.ncbi.nlm.nih.gov/pubmed/31794717
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https://pubmed.ncbi.nlm.nih.gov/PMC6897307
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