Delivery of subunit vaccines in maize seed

• Published in: Journal of controlled release Vol. 85; no. 1; pp. 169 - 180
• Main Authors: Lamphear, Barry J, Streatfield, Stephen J, Jilka, Joseph M, Brooks, Christopher A, Barker, Donna K, Turner, Debra D, Delaney, Donna E, Garcia, Martin, Wiggins, Barry, Woodard, Susan L, Hood, Elizabeth E, Tizard, Ian R, Lawhorn, Bruce, Howard, John A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 13.12.2002; Elsevier Science B.V
• Subjects: Administration, Oral; Animals; Antigen stability; Bacterial Toxins - administration & dosage; Bacterial Toxins - immunology; Chemistry, Pharmaceutical; Drug Delivery Systems - veterinary; Enterotoxins - administration & dosage; Enterotoxins - immunology; Escherichia coli heat-labile enterotoxin; Escherichia coli Infections - prevention & control; Escherichia coli Infections - veterinary; Escherichia coli Proteins; Gastroenteritis, Transmissible, of Swine - prevention & control; Mice; Mice, Inbred BALB C; Plant Extracts - administration & dosage; Plant Extracts - immunology; Plants, Genetically Modified - immunology; Seed-derived vaccine; Seeds - immunology; Seeds - microbiology; Seeds - virology; Swine; Transgenic corn; Transmissible gastroenteritis virus; Transmissible gastroenteritis virus - immunology; Vaccination - veterinary; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; Viral Proteins - administration & dosage; Viral Proteins - immunology; Zea mays - immunology; Transgenic corn; Transmissible gastroenteritis virus; Seed-derived vaccine; Antigen stability; Escherichia coli heat-labile enterotoxin

The use of recombinant gene technologies by the vaccine industry has revolutionized the way antigens are generated, and has provided safer, more effective means of protecting animals and humans against bacterial and viral pathogens. Viral and bacterial antigens for recombinant subunit vaccines have...