miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS

• Published in: Developmental cell Vol. 40; no. 6; pp. 566 - 582.e5
• Main Authors: Wang, Haibo, Moyano, Ana Lis, Ma, Zhangyan, Deng, Yaqi, Lin, Yifeng, Zhao, Chuntao, Zhang, Liguo, Jiang, Minqing, He, Xuelian, Ma, Zhixing, Lu, Fanghui, Xin, Mei, Zhou, Wenhao, Yoon, Sung Ok, Bongarzone, Ernesto R., Lu, Q. Richard
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.03.2017
• Subjects: Animals; Cell Differentiation - drug effects; Cell Lineage - drug effects; Central Nervous System - drug effects; Central Nervous System - metabolism; Central Nervous System - pathology; Demyelinating Diseases - genetics; Demyelinating Diseases - pathology; demyelinating injury; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental - genetics; Encephalomyelitis, Autoimmune, Experimental - pathology; Etv5; experimental autoimmune encephalomyelitis; Gene Deletion; gene regulatory network; Lecithins - pharmacology; Lingo1; Membrane Proteins - metabolism; Mice, Inbred C57BL; Mice, Knockout; microRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miR-219; miR-338; Multiple Sclerosis - genetics; Multiple Sclerosis - pathology; Multiple Sclerosis - therapy; Myelin Sheath - drug effects; Myelin Sheath - metabolism; Myelin Sheath - pathology; myelination; Nerve Regeneration - drug effects; Nerve Regeneration - genetics; Nerve Tissue Proteins - metabolism; Oligodendroglia - drug effects; Oligodendroglia - metabolism; Optic Nerve - pathology; Optic Nerve - ultrastructure; Phenotype; remyelination; Spinal Cord - drug effects; Spinal Cord - metabolism; Spinal Cord - pathology; Wound Healing - drug effects; Wound Healing - genetics; microRNAs; experimental autoimmune encephalomyelitis; Lingo1; myelination; miR-338; gene regulatory network; miR-219; remyelination; demyelinating injury; Etv5

A lack of sufficient oligodendrocyte myelination contributes to remyelination failure in demyelinating disorders. miRNAs have been implicated in oligodendrogenesis; however, their functions in myelin regeneration remained elusive. Through developmentally regulated targeted mutagenesis, we demonstrat...