Axillary and systemic treatment of patients with breast cancer and micrometastatic disease or isolated tumor cells in the sentinel lymph node

• Published in: Breast (Edinburgh) Vol. 21; no. 4; pp. 524 - 528
• Main Authors: Maaskant-Braat, Adriana J, Voogd, Adri C, van de Poll-Franse, Lonneke V, Coebergh, Jan Willem W, Nieuwenhuijzen, Grard A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2012
• Subjects: Adult; Aged; Aged, 80 and over; Antineoplastic Agents - therapeutic use; Axilla; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Breast Neoplasms - therapy; Chemotherapy, Adjuvant; Decision Support Techniques; Female; Hematology, Oncology and Palliative Medicine; Humans; Isolated tumor cells; Lymph Node Excision - statistics & numerical data; Lymphatic Metastasis; Mastectomy; Micrometastasis; Middle Aged; Multivariate Analysis; Neoplasm Micrometastasis; Netherlands; Practice Patterns, Physicians' - statistics & numerical data; Registries; Sentinel Lymph Node Biopsy; Treatment; Netherlands; Micrometastasis; Isolated tumor cells; Breast cancer; Treatment; Sentinel lymph node biopsy

Abstract Background After introduction of sentinel node biopsy (SNB) in patients with breast cancer a higher proportion of micrometastases and isolated tumor cells are being detected. Prognostic impact and clinical relevance of this minimal nodal involvement is under debate and substantial variation...