EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration

• Published in: Developmental cell Vol. 45; no. 6; pp. 681 - 695.e4
• Main Authors: Aiello, Nicole M., Maddipati, Ravikanth, Norgard, Robert J., Balli, David, Li, Jinyang, Yuan, Salina, Yamazoe, Taiji, Black, Taylor, Sahmoud, Amine, Furth, Emma E., Bar-Sagi, Dafna, Stanger, Ben Z.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.06.2018
• Subjects: Animals; Cadherins - metabolism; Cadherins - physiology; Cell Line, Tumor; Cell Movement - genetics; Cell Plasticity - physiology; circulating tumor cells; collective migration; E-cadherin; Epithelial Cells - physiology; epithelial-mesenchymal transition; Epithelial-Mesenchymal Transition - physiology; Gene Expression Regulation, Neoplastic - genetics; Humans; lineage tracing; metastasis; Mice; Neoplasm Invasiveness - genetics; pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - metabolism; partial EMT; Signal Transduction; Transcription Factors - metabolism; tumor cell clusters; pancreatic cancer; partial EMT; metastasis; tumor cell clusters; epithelial-mesenchymal transition; lineage tracing; circulating tumor cells; collective migration; E-cadherin

Epithelial-mesenchymal transition (EMT) is strongly implicated in tumor cell invasion and metastasis. EMT is thought to be regulated primarily at the transcriptional level through the repressive activity of EMT transcription factors. However, these classical mechanisms have been parsed out almost ex...