NADPH oxidase 5 is a novel susceptibility gene for type 2 diabetes mellitus

• Published in: Archives of Endocrinology and Metabolism Vol. 68; p. e230527
• Main Authors: Azarova, Iuliia, Klyosova, Elena, Azarova, Valentina, Polonikov, Alexey
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Endocrinologia e Metabologia 01.01.2024; Brazilian Society of Endocrinology and Metabolism
• Subjects: Adult; Aged; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2 - genetics; Female; gene-environment interactions; Genetic Predisposition to Disease - genetics; Genotype; Haplotypes - genetics; Humans; Male; Middle Aged; NADPH oxidase 5; NADPH Oxidase 5 - genetics; Original; oxidative stress; Pilot Projects; Polymorphism, Single Nucleotide - genetics; Risk Factors; single nucleotide polymorphism; Type 2 diabetes; Type 2 diabetes; NADPH oxidase 5; risk factors; gene-environment interactions; single nucleotide polymorphism; oxidative stress

This pilot study investigated whether single nucleotide polymorphisms (SNP) in the NOX5 gene (NADPH oxidase 5) are associated with the type 2 diabetes (T2D) risk. A total of 1579 patients with T2D and 1627 age- and sex-matched healthy subjects were recruited for this study. Genotyping of common SNPs...