Risk factors for the occurrence of spina bifida (a case-control study) and the prevalence rate of spina bifida in Japan

• Published in: Birth defects research. A Clinical and molecular teratology Vol. 97; no. 9; p. 610
• Main Authors: Kondo, Atsuo, Morota, Nobuhito, Ihara, Satoshi, Saisu, Takeshi, Inoue, Katsumi, Shimokawa, Shoko, Fujimaki, Hiroya, Matsuo, Keisuke, Shimosuka, Yoichi, Watanabe, Tomoyuki
• Format: Journal Article
• Language: English
• Published: United States 01.09.2013
• Subjects: Anticonvulsants - adverse effects; Case-Control Studies; Female; Folic Acid - therapeutic use; Humans; Infant, Low Birth Weight; Japan - epidemiology; Logistic Models; Odds Ratio; Pedigree; Pregnancy; Prevalence; Risk Factors; Spinal Dysraphism - epidemiology; Spinal Dysraphism - prevention & control; Surveys and Questionnaires; Japan; prevalence; supplements; risk factors; folic acid; case-control study; spina bifida

The Japanese government recommended in 2000 that women planning pregnancy should take 400 μg of folic acid daily to decrease the risk of having an infant with spina bifida. We aimed to identify risk factors for the occurrence of spina bifida and to evaluate how the prevalence rate has altered over t...