Hyperbolic Relationship Between Insulin Secretion and Sensitivity on Oral Glucose Tolerance Test

• Published in: Obesity (Silver Spring, Md.) Vol. 16; no. 8; pp. 1901 - 1907
• Main Authors: Retnakaran, Ravi, Shen, Sandy, Hanley, Anthony J., Vuksan, Vladimir, Hamilton, Jill K., Zinman, Bernard
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2008
• Subjects: Adult; Area Under Curve; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - prevention & control; Drug Therapy, Combination; Female; Glucose Tolerance Test - methods; Humans; Hypoglycemic Agents - therapeutic use; Insulin - blood; Insulin - metabolism; Insulin Resistance - physiology; Insulin Secretion; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - physiology; Metformin - therapeutic use; Prospective Studies; Reproducibility of Results; Rosiglitazone; Thiazolidinediones - therapeutic use

The utility of the disposition index as a measure of β‐cell compensatory capacity rests on the established hyperbolic relationship between its component insulin secretion and sensitivity measures as derived from the intravenous glucose tolerance test (IVGTT). If one is to derive an analogous measure...