Dysmyelopoietic syndromes a search for prognostic factors in 193 patients

Dysmyelopoietic syndromes cover sideroblastic or nonsideroblastic refractory anemia with or without excess of blasts, subacute or chronic myelomonocytic leukemia. The evolution of 193 patients was studied with regard to the initial hematologic picture. A certain number of variables of prognostic val...

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Published inCancer Vol. 52; no. 1; pp. 83 - 90
Main Authors Coiffier, Bertrand, Adeleine, Patrice, Viala, Jean J., Bryon, Paul A., Fière, Denis, Gentilhomme, Odile, Vuvan, Huan
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.07.1983
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Abstract Dysmyelopoietic syndromes cover sideroblastic or nonsideroblastic refractory anemia with or without excess of blasts, subacute or chronic myelomonocytic leukemia. The evolution of 193 patients was studied with regard to the initial hematologic picture. A certain number of variables of prognostic value have then been isolated: excess of marrow blasts (more than 5%); presence of circulating blasts or karyotypic anomalies; reduction in the number of polymorphonuclear leukocytes (less than 1.043 109/1), of monocytes (less than 0.136 109/1), of platelets (less than 140 109/1), of in vitro granulopoietic progenitors (less than 5 per 105 nucleated cells plated), of erythrocytic incorporation of 59Fe at day 14 (less than 12%), of hemoglobin level (less than 92 g/l); previous exposure to radiation or chemotherapy; early hemolysis in 51Cr‐labeled erythrocytes study; marrow heterogeneity in histology; less than 20% of ringed sideroblasts. The correlation between these variables and adjustements related to the length of survival and the order of magnitude of the critical level of the log‐rank test show that the most significant variables in descending order are: excess of marrow blasts, neutropenia, thrombopenia, presence of circulating blasts, the type of erythropoietic insufficiency, and decrease of in vitro growth. Cancer 52:83‐90, 1983.
AbstractList Dysmyelopoietic syndromes cover sideroblastic or nonsideroblastic refractory anemia with or without excess of blasts, subacute or chronic myelomonocytic leukemia. The evolution of 193 patients was studied with regard to the initial hematologic picture. A certain number of variables of prognostic value have then been isolated: excess of marrow blasts (more than 5%); presence of circulating blasts or karyotypic anomalies; reduction in the number of polymorphonuclear leukocytes (less than 1.043 109/1), of monocytes (less than 0.136 109/1), of platelets (less than 140 109/1), of in vitro granulopoietic progenitors (less than 5 per 105 nucleated cells plated), of erythrocytic incorporation of 59Fe at day 14 (less than 12%), of hemoglobin level (less than 92 g/l); previous exposure to radiation or chemotherapy; early hemolysis in 51Cr‐labeled erythrocytes study; marrow heterogeneity in histology; less than 20% of ringed sideroblasts. The correlation between these variables and adjustements related to the length of survival and the order of magnitude of the critical level of the log‐rank test show that the most significant variables in descending order are: excess of marrow blasts, neutropenia, thrombopenia, presence of circulating blasts, the type of erythropoietic insufficiency, and decrease of in vitro growth. Cancer 52:83‐90, 1983.
Dysmyelopoietic syndromes cover sideroblastic or nonsideroblastic refractory anemia with or without excess of blasts, subacute or chronic myelomonocytic leukemia. The evolution of 193 patients was studied with regard to the initial hematologic picture. A certain number of variables of prognostic value have then been isolated: excess of marrow blasts (more than 5%); presence of circulating blasts or karyotypic anomalies; reduction in the number of polymorphonuclear leukocytes (less than 1.043 10(9)/l, of monocytes (less than 0.136 10(9)/l), of platelets (less than 140 10(9)/l), of in vitro granulopoietic progenitors (less than 5 per 10(5) nucleated cells plated), of erythrocytic incorporation of 59Fe at day 14 (less than 12%), of hemoglobin level (less than 92 g/l); previous exposure to radiation or chemotherapy; early hemolysis in 51Cr-labeled erythrocytes study; marrow heterogeneity in histology; less than 20% of ringed sideroblasts. The correlation between these variables and adjustments related to the length of survival and the order of magnitude of the critical level of the log-rank test show that the most significant variables in descending order are: excess of marrow blasts, neutropenia, thrombopenia, presence of circulating blasts, the type of erythropoietic insufficiency, and decrease of in vitro growth.
Author Bryon, Paul A.
Fière, Denis
Viala, Jean J.
Coiffier, Bertrand
Adeleine, Patrice
Vuvan, Huan
Gentilhomme, Odile
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Snippet Dysmyelopoietic syndromes cover sideroblastic or nonsideroblastic refractory anemia with or without excess of blasts, subacute or chronic myelomonocytic...
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StartPage 83
SubjectTerms Anemia, Sideroblastic - complications
Blood Platelets - pathology
Bone Marrow - pathology
Female
Humans
Male
Myeloproliferative Disorders - blood
Neutropenia - complications
Prognosis
Retrospective Studies
Splenomegaly - complications
Thrombocytopenia - complications
Title Dysmyelopoietic syndromes a search for prognostic factors in 193 patients
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https://www.ncbi.nlm.nih.gov/pubmed/6850547
https://search.proquest.com/docview/80478947
Volume 52
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