The Synthesis of Novel Isoindoline Nitroxides Bearing Water-Solubilising Functionality

• Published in: European Journal of Organic Chemistry Vol. 2009; no. 12; pp. 1902 - 1915
• Main Authors: Fairfull-Smith, Kathryn E., Brackmann, Farina, Bottle, Steven E.
• Format: Book Review Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.04.2009; WILEY‐VCH Verlag; Wiley; Wiley-VCH
• Subjects: Antioxidant; Chemistry; Chemistry, Organic; Exact sciences and technology; Free radicals chemistry; Heterocyclic compounds; Heterocyclic compounds with only one n hetero atom and condensed derivatives; Isoindoline; Medicinal chemistry; Nitroxide; Organic chemistry; Physical Sciences; Preparations and properties; Radicals; Reactivity and mechanisms; Science & Technology; Medicinal chemistry; Isoindoline; ANTIOXIDANTS; TEMPOL; NITRIC-OXIDE; Nitroxide; Antioxidant; Radicals; FREE-RADICALS; Water; Nitroxyl; Molecular structure; Nitrogen heterocycle; Alcohol; Steric hindrance; Isoindole derivatives; Chemical reduction; Amine; Carboxylic acid; Steric effect; Organic free radical; Analog; Aromatic compound; Oxidation; Phosphonic acid derivatives; Chemical synthesis

A range of novel tetramethyl‐ and tetraethylisoindolinenitroxides, possessing aryl‐linked carboxylic acids, amines, alcohols and phosphonic acids were prepared. Notably, the chemistry established for the aromatic dibromination of the tetramethylisoindolines was not easily transferred to the correspo...