Sex Alters the MHC Class I HLA-A Association With Polyglandular Autoimmunity

• Published in: The journal of clinical endocrinology and metabolism Vol. 104; no. 5; pp. 1680 - 1686
• Main Authors: Flesch, Brigitte K, König, Jochem, Frommer, Lara, Hansen, Martin P, Kahaly, George J
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.05.2019; Copyright Oxford University Press; Oxford University Press
• Subjects: Adult; Alleles; Autoimmunity; Biomarkers - analysis; Case-Control Studies; Cross-Sectional Studies; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - pathology; DQA1 protein; Drb1 protein; Ethylenediaminetetraacetic acid; Female; Follow-Up Studies; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Histocompatibility antigen HLA; Histocompatibility antigens; Histocompatibility Antigens Class I - genetics; Histocompatibility Testing; HLA histocompatibility antigens; HLA-A Antigens - genetics; Humans; Immunogenetics; Major histocompatibility complex; Male; Middle Aged; Polyendocrinopathies, Autoimmune - genetics; Polyendocrinopathies, Autoimmune - immunology; Polyendocrinopathies, Autoimmune - pathology; Prognosis; Sex; Sex Factors; Thyroid diseases; Thyroiditis; Type 1 diabetes; Germany

Abstract Context The major histocompatibility complex (MHC) strongly contributes to the development of polyglandular autoimmunity (PGA). Objective To evaluate the impact of sex on human leukocyte antigen (HLA) association with PGA for the first time. Design Cross-sectional immunogenetic study. Setti...