Rapid salivary pepsin test: blinded assessment of test performance in gastroesophageal reflux disease

• Published in: The Laryngoscope Vol. 122; no. 6; p. 1312
• Main Authors: Saritas Yuksel, Elif, Hong, Shih-Kuang S, Strugala, Vicki, Slaughter, James C, Goutte, Marion, Garrett, C Gaelyn, Dettmar, Peter W, Vaezi, Michael F
• Format: Journal Article
• Language: English
• Published: United States 01.06.2012
• Subjects: Adult; Double-Blind Method; Esophageal pH Monitoring; Esophagoscopy - methods; Female; Gastroesophageal Reflux - diagnosis; Gastroscopy - methods; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Pepsin A - analysis; Prospective Studies; Reference Values; Saliva - chemistry; Sensitivity and Specificity; Severity of Illness Index; Time Factors

Pepsin lateral flow device (LFD) is a rapid noninvasive test to detect salivary pepsin as a surrogate marker for gastroesophageal reflux disease (GERD). We aimed to establish the test sensitivity, specificity, positive and negative predictive values (PPV, NPV) in patients with symptomatic and object...