Synthesis of 3-Iodoquinolines by Copper-Catalyzed Tandem Annulation from Diaryliodoniums, Nitriles, and 1-Iodoalkynes

• Published in: Advanced synthesis & catalysis Vol. 358; no. 14; pp. 2332 - 2339
• Main Authors: Wang, Xuesong, Wang, Xingyong, Huang, Dayun, Liu, Chulong, Wang, Xinyan, Hu, Yuefei
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 14.07.2016; WILEY‐VCH Verlag; Wiley
• Subjects: 1-iodoalkynes; annulation; Catalysis; Chemical reactions; Chemistry; Chemistry, Applied; Chemistry, Organic; copper catalysts; iodoniums; Nitriles; Organic chemistry; Physical Sciences; Science & Technology; Synthesis; synthesis of quinolones; tandem reactions; ELECTROPHILIC CYCLIZATION; PALLADIUM; 1-iodoalkynes; iodoniums; ONE-POT SYNTHESIS; synthesis of quinolones; 3-HALOQUINOLINES; ORGANIC AZIDES; ALKYNES; annulation; REGIOSELECTIVE SYNTHESIS; OPTIMIZATION; copper catalysts; DERIVATIVES; tandem reactions; SUBSTITUTED QUINOLINES

A novel method for the synthesis of 3‐iodoquinolines was developed by copper‐catalyzed tandem annulation from diaryliodoniums, nitriles, and 1‐iodoalkynes. It is a method that is characterized by the most convenient operation and wide molecular diversity.