Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood

• Published in: The journal of clinical endocrinology and metabolism Vol. 104; no. 10; pp. 4521 - 4530
• Main Authors: Bauer, Witold, Veijola, Riitta, Lempainen, Johanna, Kiviniemi, Minna, Härkönen, Taina, Toppari, Jorma, Knip, Mikael, Gyenesei, Attila, Ilonen, Jorma
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.10.2019; Copyright Oxford University Press; Oxford University Press
• Subjects: Age; Analysis; Autoantibodies; Autoimmunity; Childhood; Children; Development and progression; Diabetes; Diabetes mellitus (insulin dependent); Genetic aspects; Genotypes; Glutamate; Glutamate decarboxylase; Glutamic acid; Histocompatibility antigen HLA; Insulin; Seroconversion; Statistical analysis; Type 1 diabetes; Finland

Abstract Context Children with initial autoantibodies to either insulin (IAA) or glutamic acid decarboxylase (GADA) differ in peak age of seroconversion and have different type 1 diabetes (T1D) risk gene associations, suggesting heterogeneity in the disease process. Objective To compare the associat...