Single-Dose Ondansetron Prevents Postoperative Vomiting in Pediatric Outpatients

• Published in: Anesthesia and analgesia Vol. 85; no. 3; pp. 538 - 545
• Main Authors: Patel, Ramesh I, Davis, Peter J, Orr, Rosemary J, Ferrari, Lynne R, Rimar, Stephen, Hannallah, Raafat S, Cohen, Ira T, Colingo, Kelly, Donlon, John V, Haberkern, Charles M, McGowan, Francis X, Prillaman, Barbara A, Parasuraman, T. V, Creed, Mary R
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD International Anesthesia Research Society 01.09.1997; Lippincott
• Subjects: Anesthesia, General; Anesthetics, Inhalation; Antiemetics - administration & dosage; Antiemetics - adverse effects; Biological and medical sciences; Child; Child, Preschool; Digestive system; Double-Blind Method; Female; Halothane; Humans; Length of Stay; Male; Medical sciences; Nitrous Oxide; Ondansetron - administration & dosage; Ondansetron - adverse effects; Pharmacology. Drug treatments; Postoperative Complications - prevention & control; Premedication; Vomiting - prevention & control; Human; Postoperative; General anesthesia; Prevention; Chemotherapy; Vomiting; Surgery; Digestive diseases; Complication; Ambulatory; Antagonist; Child; Antiemetic; Ondansetron; 5-HT3 receptor

This randomized, double-blind, parallel-group, multicenter study evaluated the safety and efficacy of ondansetron (0.1 mg/kg to 4 mg intravenously) compared with placebo in the prevention of postoperative vomiting in 429 ASA status I-III children 1-12 yr old undergoing outpatient surgery under nitro...