Long-Term Therapy of Chronic Hepatitis B With Lamivudine

• Published in: Hepatology (Baltimore, Md.) Vol. 32; no. 4; pp. 828 - 834
• Main Authors: Lau, Daryl T, Farooq Khokhar, M, Doo, Edward, Ghany, Marc G, Herion, David, Park, Yoon, Kleiner, David E, Schmid, Peter, Condreay, Lynn D, Gauthier, Josée, Kuhns, Mary C, Jake Liang, T, Hoofnagle, Jay H
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01.10.2000; W.B. Saunders; Wiley
• Subjects: Adult; Aged; Alanine Transaminase - blood; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; DNA, Viral - analysis; Drug Resistance; Female; Hepatitis B e Antigens - analysis; Hepatitis B Surface Antigens - analysis; Hepatitis B, Chronic - drug therapy; Hepatitis B, Chronic - pathology; Hepatitis B, Chronic - virology; Humans; Lamivudine - adverse effects; Lamivudine - therapeutic use; Liver - pathology; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Reverse Transcriptase Inhibitors - therapeutic use; Human; Hepatic disease; Lamivudine; Long term; Infection; Viral hepatitis B; Chemotherapy; Chronic; Viral disease; Dideoxynucleoside; Digestive diseases; Antiviral; Pyrimidine nucleoside

Lamivudine therapy induces improvements in chronic hepatitis B in a high proportion of patients, but prolonged therapy is limited by the development of viral resistance. We analyzed clinical responses and virologic resistance in 27 patients treated continuously with lamivudine for 2 to 4 years. Seru...