Effect of Prebiotic on Microbiota, Intestinal Permeability, and Glycemic Control in Children With Type 1 Diabetes

• Published in: The journal of clinical endocrinology and metabolism Vol. 104; no. 10; pp. 4427 - 4440
• Main Authors: Ho, Josephine, Nicolucci, Alissa C, Virtanen, Heidi, Schick, Alana, Meddings, Jon, Reimer, Raylene A, Huang, Carol
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.10.2019; Copyright Oxford University Press; Oxford University Press
• Subjects: Abundance; Academic Medical Centers; Adolescent; Age; Blood Glucose - analysis; Blood Glucose - drug effects; Canada; Carbohydrates; Child; Children; Clinical trials; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - diagnosis; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - microbiology; Diabetes therapy; Diabetic ketoacidosis; Digestive system; Double-Blind Method; Female; Gastrointestinal Microbiome - drug effects; Gastrointestinal tract; Glucose; Glycosylated hemoglobin; Humans; Hypoglycemia; Insulin; Intestinal Absorption - drug effects; Intestinal microflora; Intestine; Inulin; Ketoacidosis; Male; Microbiota; Microbiota (Symbiotic organisms); Peptides; Permeability; Permeability - drug effects; Pilot Projects; Prebiotics; Prebiotics - administration & dosage; Prognosis; Reference Values; Treatment Outcome; Type 2 diabetes; Canada; Alberta

Abstract Context Patients with type 1 diabetes (T1D) have lower microbiota diversity and distinct gut microbial profiles that have been linked to changes in intestinal permeability. Prebiotics are nondigestible carbohydrates that alter gut microbiota and could potentially improve glycemic control an...