Copper-Catalyzed Trifluoromethylation and Bicyclizations of 1,7-Enynes Leading to Fused Polycycles

• Published in: Advanced synthesis & catalysis Vol. 358; no. 21; pp. 3435 - 3442
• Main Authors: Wang, Qiang, Song, Hongjian, Liu, Yuxiu, Song, Haibin, Wang, Qingmin
• Format: Journal Article
• Language: English
• Published: WEINHEIM Blackwell Publishing Ltd 03.11.2016; Wiley
• Subjects: Agricultural chemicals; Catalysis; Chemistry; Chemistry, Applied; Chemistry, Organic; Fungi; fungicidal activity; Fungicides; fused polycycles; Indene; Organic chemistry; Physical Sciences; radical cascade reaction; Radicals; Science & Technology; Synthesis (chemistry); trifluoromethylation; fungicidal activity; CARBOCYCLIZATION; radical cascade reaction; BOND FORMATION; fused polycycles; ALKENES; ARYLTRIFLUOROMETHYLATION; DEAROMATIZATION ACCESS; LIGHT-INDUCED TRIFLUOROMETHYLATION; CONSTRUCTION; FLUORINE; trifluoromethylation; CYCLIZATION; 1,N-ENYNES

A series of trifluoromethyl‐containing heterocycles, like indene and dihydroquinolinone or dihydrocoumarin‐fused tetracyclic compounds have been prepared using copper‐catalyzed cascade reaction of benzene‐tethered 1,7‐enynes. A study of the mechanism indicated that radical trifluoromethylation and s...