NK Cell Dysfunction and Checkpoint Immunotherapy

• Published in: Frontiers in immunology Vol. 10; p. 1999
• Main Authors: Bi, Jiacheng, Tian, Zhigang
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.08.2019
• Subjects: checkpoint blockade; immune evasion; immune tolerance; Immunology; inhibitory receptors; regional immunity; checkpoint blockade; immune tolerance; regional immunity; immune evasion; inhibitory receptors

NK cells play important roles in the innate immune responses against tumors. The effector function of NK cells relies on the integration of activating and inhibitory signals. Emerging checkpoint receptors and molecules are being revealed to mediate NK cell dysfunction in the tumor microenvironment....