Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not - Niculescu, Mihai D; da Costa, Kerry-Ann; Fischer, Leslie M; Zeisel, Steven H (The American journal of clinical nutrition, 2007)
Keywords: administration & dosage; Adult; adults; Aged; apoptosis; Biological and medical sciences; biosynthesis; blood; blood chemistry; chemistry; choline; Choline - administration & dosage; Choline Deficiency; Choline Deficiency - blood; Choline Deficiency - enzymology; Choline Deficiency - genetics; Choline Dehydrogenase; Choline Dehydrogenase - biosynthesis; Choline Dehydrogenase - genetics; Cluster Analysis; DNA; DNA - chemistry; DNA - genetics; enzymology; fatty liver; Feeding. Feeding behavior; Female; folic acid; Fundamental and applied biological sciences. Psychology; gene expression; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; genetics; genotype; health status; Humans; liver diseases; lymphocytes; Lymphocytes - enzymology; Lymphocytes - metabolism; Lymphocytes - physiology; Male; men; metabolism; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Dehydrogenase (NADP) - biosynthesis; Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics; Middle Aged; nutrient deficiencies; nutrient intake; nutritional status; Oligonucleotide Array Sequence Analysis; organ dysfunction; phenotype; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamine N-Methyltransferase - biosynthesis; Phosphatidylethanolamine N-Methyltransferase - genetics; physiology; Polymorphism, Single Nucleotide; single nucleotide polymorphism; skeletal muscle; Vertebrates: anatomy and physiology, studies on body, several organs or systems; vitamin metabolism; women; Choline dehydrogenase; Dehydrogenase; methylenetetrahydrofolate dehydrogenase; choline; Phosphatidylethanolamine N-methyltransferase; MTHFD; single-nucleotide polymorphism; WHO; Human; choline deficiency; lymphocytes; Enzyme; Transferases; Deficiency; Gene expression; phosphatidylethanolamine methyltransferase; Feeding; Methyltransferases; Diet; Low; Dysfunction; CHDH; Nucleotide; PEMT; Oxidoreductases; Lymphocyte; Polymorphism