Repeated measures dose-finding design with time-trend detection in the presence of correlated toxicity data - Yin, Jun; Paoletti, Xavier; Sargent, Daniel J; Mandrekar, Sumithra J (Clinical trials (London, England), 2017)
Keywords: Antibiotics, Antineoplastic - adverse effects; Antibiotics, Antineoplastic - toxicity; Antineoplastic Agents - toxicity; Bayes Theorem; Clinical Trials, Phase I as Topic - methods; Depsipeptides - adverse effects; Depsipeptides - toxicity; Dose-Response Relationship, Drug; Endpoint Determination - methods; Humans; Immunotherapy - adverse effects; Linear Models; Longitudinal Studies; Maximum Tolerated Dose; Molecular Targeted Therapy - adverse effects; Neoplasms - drug therapy; molecularly targeted agents; adaptive; maximum tolerated dose; correlated toxicity; immunotherapy; Dose-finding; continual reassessment method; time trend; phase I clinical trials; repeated measures