Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

• Published in: World journal of gastroenterology : WJG Vol. 24; no. 27; pp. 2974 - 2983
• Main Authors: Fang, Yan-Lan, Chen, Hong, Wang, Chun-Lin, Liang, Li
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 21.07.2018
• Subjects: Review; Nonalcoholic fatty liver disease; Children; Adolescents; Non-alcoholic steatohepatitis; Pathogenesis

Nonalcoholic fatty liver disease (NAFLD) has become the dominant form of chronic liver disease in children and adolescents with the increasing prevalence of obesity worldwide. NAFLD represents a wide spectrum of conditions, ranging from fatty liver - which generally follows a benign, non-progressive...