Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites

• Published in: Frontiers in microbiology Vol. 6; p. 903
• Main Authors: Chávez, Renato, Fierro, Francisco, García-Rico, Ramón O., Vaca, Inmaculada
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09.09.2015
• Subjects: extreme environments; Filamentous fungi; genome mining; Metagenomics; Microbiology; Natural Products; secondary metabolites; extreme environments; natural products; filamentous fungi; secondary metabolites; metagenomics; genome mining

Natural product search is undergoing resurgence upon the discovery of a huge previously unknown potential for secondary metabolite (SM) production hidden in microbial genomes. This is also the case for filamentous fungi, since their genomes contain a high number of "orphan" SM gene cluster...