Genetic and Non-genetic Factors Contributing to the Significant Variation in the Plasma Trough Concentration-to-Dose Ratio of Valproic Acid in Children With Epilepsy

• Published in: Frontiers in pediatrics Vol. 8; p. 599044
• Main Authors: Xu, Ze-Yue, Guo, Hong-Li, Li, Ling, Zhang, Min, Jing, Xia, Xu, Ze-Jun, Qiu, Jin-Chun, Lu, Xiao-Peng, Ding, Xuan-Sheng, Chen, Feng, Xu, Jing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.01.2021
• Subjects: C0/D ratio; children; dosage form; epilepsy; Pediatrics; therapeutic drug monitoring; valproic acid; epilepsy; dosage form; children; C0/D ratio; polymorphism; valproic acid; therapeutic drug monitoring

Objective: This study was conducted to evaluate the potential genetic and non-genetic factors contributing to plasma trough concentration-to-dose ( C 0 / D ) ratio of valproic acid (VPA) in pediatric patients with epilepsy. Study Design: A single-center, retrospective cohort study was performed by c...