Intraoperative changes in the H-reflex pathway during deep brain stimulation surgery for Parkinson’s disease: A potential biomarker for optimal electrode placement

• Published in: Brain stimulation Vol. 13; no. 6; pp. 1765 - 1773
• Main Authors: Andrews, Jennifer C., Roy, François D., Ba, Fang, Sankar, Tejas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2020; Elsevier
• Subjects: Adult; Aged; Biomarker; Biomarkers; Deep brain stimulation; Deep Brain Stimulation - methods; Deep Brain Stimulation - trends; Electrodes, Implanted - trends; Female; Globus Pallidus - physiology; Globus pallidus interna; H-reflex; H-Reflex - physiology; Humans; Intraoperative Neurophysiological Monitoring - methods; Intraoperative Neurophysiological Monitoring - trends; Male; Microelectrodes - trends; Middle Aged; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Subthalamic nucleus; Subthalamic Nucleus - physiology; Treatment Outcome; Wakefulness - physiology; Biomarker; Subthalamic nucleus; Deep brain stimulation; H-reflex; Globus pallidus interna

Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) and globus pallidus interna (GPi) is an effective treatment for cardinal motor symptoms and motor complications in Parkinson’s Disease (PD). However, malpositioned DBS electrodes can result in suboptimal therapeutic response. We ex...