A lysosome-targeting viscosity-sensitive fluorescent probe based on a novel functionalised near-infrared xanthene-indolium dye and its application in living cells

The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g. , locations, morphologies, and components. Herein, we constructed a novel near-infrared (NIR) lysosome-targeting viscosity probe, Lyso-cy , for...

Full description

Saved in:
Bibliographic Details
Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 8; no. 38; pp. 8838 - 8844
Main Authors Liu, Chang, Zhao, Tong, He, Song, Zhao, Liancheng, Zeng, Xianshun
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 07.10.2020
Subjects
Biological activity
Biomonitoring
Cells (biology)
Confocal microscopy
Fluorescence
fluorescent dyes
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent indicators
Glycerol
HeLa Cells
Humans
I.R. radiation
indoles
Indoles - chemical synthesis
Indoles - chemistry
Lysosomes
Lysosomes - chemistry
Lysosomes - metabolism
Microscopy, Confocal - methods
Microscopy, Fluorescence - methods
Morphology
near infrared radiation
Organoselenium Compounds - chemical synthesis
Organoselenium Compounds - chemistry
Temporal resolution
Viscosity
Xanthene
xanthenes
Xanthenes - chemical synthesis
Xanthenes - chemistry
Online AccessGet full text

Cover

Abstract The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g. , locations, morphologies, and components. Herein, we constructed a novel near-infrared (NIR) lysosome-targeting viscosity probe, Lyso-cy , for monitoring viscosity changes in biological systems. The Lyso-cy probe showed very strong fluorescence emission at around 710 nm in viscous media. The fluorescence intensity of Lyso-cy increased 122-fold from when in water to when in 95% glycerol. Moreover, Lyso-cy proved to be an ideal lysosome-targeting tracer for monitoring fluctuations in the viscosity of a living cell with high spatial and temporal resolution under laser confocal microscopy. The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g. , locations, morphologies, and components.
AbstractList The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g. , locations, morphologies, and components. Herein, we constructed a novel near-infrared (NIR) lysosome-targeting viscosity probe, Lyso-cy , for monitoring viscosity changes in biological systems. The Lyso-cy probe showed very strong fluorescence emission at around 710 nm in viscous media. The fluorescence intensity of Lyso-cy increased 122-fold from when in water to when in 95% glycerol. Moreover, Lyso-cy proved to be an ideal lysosome-targeting tracer for monitoring fluctuations in the viscosity of a living cell with high spatial and temporal resolution under laser confocal microscopy.
The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g., locations, morphologies, and components. Herein, we constructed a novel near-infrared (NIR) lysosome-targeting viscosity probe, Lyso-cy, for monitoring viscosity changes in biological systems. The Lyso-cy probe showed very strong fluorescence emission at around 710 nm in viscous media. The fluorescence intensity of Lyso-cy increased 122-fold from when in water to when in 95% glycerol. Moreover, Lyso-cy proved to be an ideal lysosome-targeting tracer for monitoring fluctuations in the viscosity of a living cell with high spatial and temporal resolution under laser confocal microscopy.
The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g., locations, morphologies, and components. Herein, we constructed a novel near-infrared (NIR) lysosome-targeting viscosity probe, Lyso-cy, for monitoring viscosity changes in biological systems. The Lyso-cy probe showed very strong fluorescence emission at around 710 nm in viscous media. The fluorescence intensity of Lyso-cy increased 122-fold from when in water to when in 95% glycerol. Moreover, Lyso-cy proved to be an ideal lysosome-targeting tracer for monitoring fluctuations in the viscosity of a living cell with high spatial and temporal resolution under laser confocal microscopy.The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g., locations, morphologies, and components. Herein, we constructed a novel near-infrared (NIR) lysosome-targeting viscosity probe, Lyso-cy, for monitoring viscosity changes in biological systems. The Lyso-cy probe showed very strong fluorescence emission at around 710 nm in viscous media. The fluorescence intensity of Lyso-cy increased 122-fold from when in water to when in 95% glycerol. Moreover, Lyso-cy proved to be an ideal lysosome-targeting tracer for monitoring fluctuations in the viscosity of a living cell with high spatial and temporal resolution under laser confocal microscopy.
The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g. , locations, morphologies, and components. Herein, we constructed a novel near-infrared (NIR) lysosome-targeting viscosity probe, Lyso-cy , for monitoring viscosity changes in biological systems. The Lyso-cy probe showed very strong fluorescence emission at around 710 nm in viscous media. The fluorescence intensity of Lyso-cy increased 122-fold from when in water to when in 95% glycerol. Moreover, Lyso-cy proved to be an ideal lysosome-targeting tracer for monitoring fluctuations in the viscosity of a living cell with high spatial and temporal resolution under laser confocal microscopy. The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g. , locations, morphologies, and components.
Author Zhao, Tong
Zeng, Xianshun
Zhao, Liancheng
Liu, Chang
He, Song
AuthorAffiliation Ministry of Education
Harbin Institute of Technology
School of Materials Science and Engineering
School of Materials Science & Engineering
Tianjin University of Technology
Tianjin Key Laboratory for Photoelectric Materials and Devices
Institute of Information Functional Materials& Devices
Key Laboratory of Display Materials and Photoelectric Devices
AuthorAffiliation_xml – name: School of Materials Science & Engineering
– name: Tianjin Key Laboratory for Photoelectric Materials and Devices
– name: Institute of Information Functional Materials& Devices
– name: Tianjin University of Technology
– name: School of Materials Science and Engineering
– name: Ministry of Education
– name: Harbin Institute of Technology
– name: Key Laboratory of Display Materials and Photoelectric Devices
Author_xml – sequence: 1
  givenname: Chang
  surname: Liu
  fullname: Liu, Chang
– sequence: 2
  givenname: Tong
  surname: Zhao
  fullname: Zhao, Tong
– sequence: 3
  givenname: Song
  surname: He
  fullname: He, Song
– sequence: 4
  givenname: Liancheng
  surname: Zhao
  fullname: Zhao, Liancheng
– sequence: 5
  givenname: Xianshun
  surname: Zeng
  fullname: Zeng, Xianshun
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33026403$$D View this record in MEDLINE/PubMed
BookMark eNqFks1u1DAQgC1UREvphTvIqBdUKeDYSdY-tgsUpEpc9sAt8trj4sqxg-2s2Nfpk9bZbYtUIfBl_r4ZzYznJTrwwQNCr2vyoSZMfNQkr0nNqFDP0BElLakWbc0PHnXy4xCdpHRDyuN1x1nzAh0yRmjXEHaEbs-x26aQwgBVlvEasvXXeGOTCsnmbZXAF2k3gI2bQoSkwGc8xrAGvJYJNA4eS-zDBhw2k1fZBi-dnSMeZKysN1HGYv2WPv8ED8Wjg7PTgPUWsPQa25ywHEdnlZyzsfXY2c3chwLn0iv03EiX4OReHqPVl8-r5dfq6vvlt-X5VaWajuYKFGVCyFY3zKiiS8WhjLkQnRSKGmhqQwh0pFhKdK1oWqN1R5nhrOiCHaP3-7JluF8TpNwPZQulAekhTKmngrfdgnDR_h9tGlFzShYzevoEvQlTLBvaUZw3jHZ1od7eU9N6AN2P0Q4ybvuHfyoA2QMqhpQimF7ZvNtWjtK6vib9fA39J7K62F3DsqScPUl5qPpX-M0ejkk9cn9Oq8Tf_Svej9qwOzwZzBw
CitedBy_id crossref_primary_10_1016_j_talanta_2022_123235
crossref_primary_10_1021_acsaom_3c00159
crossref_primary_10_1016_j_talanta_2024_126028
crossref_primary_10_1039_D2TB00181K
crossref_primary_10_1016_j_dyepig_2023_111308
crossref_primary_10_1016_j_foodchem_2023_137755
crossref_primary_10_1016_j_dyepig_2021_109293
crossref_primary_10_1016_j_aca_2023_342184
crossref_primary_10_1016_j_microc_2023_109010
crossref_primary_10_1021_acs_analchem_2c04133
crossref_primary_10_1016_j_saa_2021_120228
crossref_primary_10_1016_j_saa_2021_120404
crossref_primary_10_1016_j_cclet_2023_108516
crossref_primary_10_1016_j_dyepig_2021_109796
crossref_primary_10_1021_acs_analchem_2c02235
crossref_primary_10_1016_j_dyepig_2022_110382
crossref_primary_10_1016_j_saa_2022_121519
crossref_primary_10_1007_s11426_023_1661_6
crossref_primary_10_6023_cjoc202203039
crossref_primary_10_1016_j_saa_2024_124540
crossref_primary_10_1021_acs_chemrev_3c00573
crossref_primary_10_1039_D1TB02639A
crossref_primary_10_1021_cbmi_3c00128
crossref_primary_10_3390_bios13030360
crossref_primary_10_1016_j_saa_2022_121368
crossref_primary_10_1088_2050_6120_ac4e73
crossref_primary_10_1016_j_saa_2022_120917
crossref_primary_10_1016_j_snb_2022_131594
crossref_primary_10_1016_j_snb_2024_136441
crossref_primary_10_1016_j_snb_2021_131015
crossref_primary_10_1039_D1CC01104A
crossref_primary_10_1016_j_snb_2022_132003
crossref_primary_10_1039_D1DT03900H
Cites_doi 10.1021/acs.accounts.6b00292
10.1039/C8TB03353F
10.1016/j.snb.2013.09.062
10.1016/j.snb.2020.127764
10.1021/acs.accounts.7b00087
10.1039/C9CC01068H
10.1091/mbc.e12-08-0617
10.1016/j.dyepig.2017.10.002
10.1097/00004872-200202000-00001
10.1021/acsami.5b10607
10.1016/j.snb.2018.05.055
10.1039/c3cc39269d
10.1039/C7CS00240H
10.1021/acs.analchem.6b01256
10.1039/C7CC06220F
10.1016/S0962-8924(00)01847-X
10.1038/nrm2217
10.1039/C8OB01701H
10.1021/acs.analchem.8b00590
10.1039/C7OB00538E
10.1016/j.snb.2019.01.045
10.1039/C9TB02609F
10.1016/j.snb.2019.127271
10.1002/slct.201703131
10.1016/j.dyepig.2018.07.001
10.1039/C9CC01263J
10.1039/C6TB02463G
10.1039/C7TB02414B
10.1016/j.saa.2018.05.121
10.1021/acs.chemrev.7b00449
10.1021/ja056370a
10.1021/acs.analchem.8b01631
10.1039/C7TB02615C
10.1016/j.tetlet.2018.11.009
10.1021/acs.analchem.9b02782
10.1039/C4CS00051J
10.1039/C1CS15168A
10.1016/j.dyepig.2015.10.012
10.1039/C7CC03417B
10.1021/ja403851p
10.1021/ja311688g
10.1021/ja800570d
10.1039/b211130f
10.1038/nrm1423
10.1038/srep05418
10.1002/3527601791
10.1038/nrc1738
10.1016/j.microc.2020.105191
10.1002/chem.201801918
10.1016/j.dyepig.2019.04.049
10.1039/c0ob01060j
10.1021/jacs.6b04048
10.1016/j.dyepig.2012.09.010
10.1002/anie.201609895
10.1021/acs.analchem.9b02678
10.1039/C9CC00113A
10.1016/j.dyepig.2019.107709
10.1039/C9TB00043G
10.1016/S0006-291X(02)00422-9
10.1039/C9OB02188D
10.1021/acs.analchem.9b01293
10.1002/anie.201507031
10.1023/B:JOFL.0000031828.96368.c1
10.1021/ja500315x
10.1039/C0CC04589F
10.1524/zpch.1971.75.1_2.063
10.1038/nrm2745
10.1016/j.snb.2018.08.109
ContentType Journal Article
Copyright Copyright Royal Society of Chemistry 2020
Copyright_xml – notice: Copyright Royal Society of Chemistry 2020
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7U5
8BQ
8FD
F28
FR3
H8D
H8G
JG9
JQ2
K9.
KR7
L7M
L~C
L~D
P64
7X8
7S9
L.6
DOI 10.1039/d0tb01329c
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Aluminium Industry Abstracts
Biotechnology Research Abstracts
Ceramic Abstracts
Computer and Information Systems Abstracts
Corrosion Abstracts
Electronics & Communications Abstracts
Engineered Materials Abstracts
Materials Business File
Mechanical & Transportation Engineering Abstracts
Solid State and Superconductivity Abstracts
METADEX
Technology Research Database
ANTE: Abstracts in New Technology & Engineering
Engineering Research Database
Aerospace Database
Copper Technical Reference Library
Materials Research Database
ProQuest Computer Science Collection
ProQuest Health & Medical Complete (Alumni)
Civil Engineering Abstracts
Advanced Technologies Database with Aerospace
Computer and Information Systems Abstracts – Academic
Computer and Information Systems Abstracts Professional
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Materials Research Database
Civil Engineering Abstracts
Aluminium Industry Abstracts
Technology Research Database
Computer and Information Systems Abstracts – Academic
Mechanical & Transportation Engineering Abstracts
Electronics & Communications Abstracts
ProQuest Computer Science Collection
Computer and Information Systems Abstracts
ProQuest Health & Medical Complete (Alumni)
Ceramic Abstracts
Materials Business File
METADEX
Biotechnology and BioEngineering Abstracts
Computer and Information Systems Abstracts Professional
Aerospace Database
Copper Technical Reference Library
Engineered Materials Abstracts
Biotechnology Research Abstracts
Solid State and Superconductivity Abstracts
Engineering Research Database
Corrosion Abstracts
Advanced Technologies Database with Aerospace
ANTE: Abstracts in New Technology & Engineering
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList CrossRef
AGRICOLA
MEDLINE - Academic
Materials Research Database

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 2050-7518
EndPage 8844
ExternalDocumentID 33026403
10_1039_D0TB01329C
d0tb01329c
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID 0-7
0R
4.4
53G
705
AAEMU
AAGNR
AAIWI
AANOJ
ABDVN
ABGFH
ABRYZ
ACGFS
ACIWK
ACLDK
ACPRK
ADMRA
ADSRN
AENEX
AFRAH
AFVBQ
AGSTE
AGSWI
ALMA_UNASSIGNED_HOLDINGS
ASKNT
AUDPV
BLAPV
BSQNT
C6K
CKLOX
D0L
EBS
ECGLT
EE0
EF-
GNO
HZ
H~N
J3I
JG
O-G
O9-
R7C
RCNCU
RIG
RNS
RPMJG
RRC
RSCEA
SKA
SKF
SLH
UCJ
0R~
AAJAE
AAWGC
AAXHV
AAYXX
ABASK
ABEMK
ABJNI
ABPDG
ABXOH
AEFDR
AENGV
AESAV
AETIL
AFLYV
AFOGI
AFRDS
AFRZK
AGEGJ
AGRSR
AHGCF
AKMSF
ALUYA
ANUXI
APEMP
CITATION
GGIMP
H13
HZ~
RAOCF
-JG
CGR
CUY
CVF
ECM
EIF
NPM
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7U5
8BQ
8FD
F28
FR3
H8D
H8G
JG9
JQ2
K9.
KR7
L7M
L~C
L~D
P64
7X8
7S9
L.6
ID FETCH-LOGICAL-c462t-ec2399a5d43fcc23ac8e302796a9c2fe41f00e60a9cc965945fdd623f8394593
ISSN 2050-750X
2050-7518
IngestDate Fri Jul 11 15:29:59 EDT 2025
Fri Jul 11 16:22:11 EDT 2025
Mon Jun 30 07:59:48 EDT 2025
Wed Feb 19 02:28:55 EST 2025
Thu Apr 24 23:06:39 EDT 2025
Tue Jul 01 01:00:28 EDT 2025
Sat Jan 08 03:54:58 EST 2022
Wed Nov 11 00:36:16 EST 2020
IsPeerReviewed true
IsScholarly true
Issue 38
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c462t-ec2399a5d43fcc23ac8e302796a9c2fe41f00e60a9cc965945fdd623f8394593
Notes Electronic supplementary information (ESI) available. See DOI
10.1039/d0tb01329c
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-7761-0198
PMID 33026403
PQID 2448843261
PQPubID 2047522
PageCount 7
ParticipantIDs crossref_citationtrail_10_1039_D0TB01329C
proquest_journals_2448843261
rsc_primary_d0tb01329c
proquest_miscellaneous_2449182075
crossref_primary_10_1039_D0TB01329C
pubmed_primary_33026403
proquest_miscellaneous_2985670895
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20201007
PublicationDateYYYYMMDD 2020-10-07
PublicationDate_xml – month: 10
  year: 2020
  text: 20201007
  day: 7
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Cambridge
PublicationTitle Journal of materials chemistry. B, Materials for biology and medicine
PublicationTitleAlternate J Mater Chem B
PublicationYear 2020
Publisher Royal Society of Chemistry
Publisher_xml – name: Royal Society of Chemistry
References Wu (D0TB01329C-(cit7c)/*[position()=1]) 2019; 168
Hua (D0TB01329C-(cit8b)/*[position()=1]) 2018; 149
Wang (D0TB01329C-(cit4b)/*[position()=1]) 2013; 135
Lu (D0TB01329C-(cit9a)/*[position()=1]) 2016; 55
Dell’Angelica (D0TB01329C-(cit22c)/*[position()=1]) 2000; 14
Zhang (D0TB01329C-(cit8a)/*[position()=1]) 2019; 7
Saftig (D0TB01329C-(cit3a)/*[position()=1]) 2009; 10
Yin (D0TB01329C-(cit7m)/*[position()=1]) 2019; 91
Guo (D0TB01329C-(cit7h)/*[position()=1]) 2018; 6
Haidekker (D0TB01329C-(cit7a)/*[position()=1]) 2006; 128
Park (D0TB01329C-(cit23a)/*[position()=1]) 2020; 309
Chao (D0TB01329C-(cit14a)/*[position()=1]) 2019; 285
Eto (D0TB01329C-(cit2b)/*[position()=1]) 2002; 293
Li (D0TB01329C-(cit10c)/*[position()=1]) 2019; 91
Han (D0TB01329C-(cit7e)/*[position()=1]) 2018; 277
Li (D0TB01329C-(cit21a)/*[position()=1]) 2011; 9
Li (D0TB01329C-(cit21c)/*[position()=1]) 2013; 96
Liu (D0TB01329C-(cit23b)/*[position()=1]) 2016; 138
Gong (D0TB01329C-(cit1e)/*[position()=1]) 2020; 158
Abeywickrama (D0TB01329C-(cit12b)/*[position()=1]) 2017; 53
Xu (D0TB01329C-(cit22b)/*[position()=1]) 2016; 4
Simon (D0TB01329C-(cit2a)/*[position()=1]) 2002; 20
Förster (D0TB01329C-(cit16)/*[position()=1]) 1971; 75
Zhu (D0TB01329C-(cit6b)/*[position()=1]) 2016; 49
Luzio (D0TB01329C-(cit3b)/*[position()=1]) 2007; 8
Lou (D0TB01329C-(cit19)/*[position()=1]) 2013; 49
Sun (D0TB01329C-(cit6d)/*[position()=1]) 2019; 171
Abeywickrama (D0TB01329C-(cit12a)/*[position()=1]) 2019; 55
Zhang (D0TB01329C-(cit7k)/*[position()=1]) 2019; 91
Kroemer (D0TB01329C-(cit18)/*[position()=1]) 2005; 5
Liu (D0TB01329C-(cit4a)/*[position()=1]) 2015; 4
Yang (D0TB01329C-(cit1b)/*[position()=1]) 2014; 43
Liu (D0TB01329C-(cit6a)/*[position()=1]) 2017; 15
Liu (D0TB01329C-(cit7o)/*[position()=1]) 2018; 59
Wu (D0TB01329C-(cit9b)/*[position()=1]) 2016; 55
Hurnak (D0TB01329C-(cit24)/*[position()=1]) 1995; 14
Sudheesh (D0TB01329C-(cit13b)/*[position()=1]) 2018; 24
Cheng (D0TB01329C-(cit1a)/*[position()=1]) 2012; 41
Yang (D0TB01329C-(cit2c)/*[position()=1]) 2013; 135
Wang (D0TB01329C-(cit7l)/*[position()=1]) 2018; 203
Li (D0TB01329C-(cit17)/*[position()=1]) 2018; 90
Wrobel (D0TB01329C-(cit9c)/*[position()=1]) 2014; 136
Wu (D0TB01329C-(cit6c)/*[position()=1]) 2017; 46
Cai (D0TB01329C-(cit11a)/*[position()=1]) 2020; 8
Wang (D0TB01329C-(cit7n)/*[position()=1]) 2016; 125
Guo (D0TB01329C-(cit7b)/*[position()=1]) 2018; 271
Tan (D0TB01329C-(cit7i)/*[position()=1]) 2019; 55
Shi (D0TB01329C-(cit14b)/*[position()=1]) 2019; 7
Shen (D0TB01329C-(cit7g)/*[position()=1]) 2020; 304
Chen (D0TB01329C-(cit9d)/*[position()=1]) 2017; 50
Sudheesh (D0TB01329C-(cit13a)/*[position()=1]) 2018; 3
Luby-Phelps (D0TB01329C-(cit1d)/*[position()=1]) 2013; 24
Kuimova (D0TB01329C-(cit5b)/*[position()=1]) 2008; 130
Liu (D0TB01329C-(cit14e)/*[position()=1]) 2019; 160
Wang (D0TB01329C-(cit14d)/*[position()=1]) 2018; 16
Simonsa (D0TB01329C-(cit5c)/*[position()=1]) 2000; 10
Hou (D0TB01329C-(cit7j)/*[position()=1]) 2018; 90
Velapoldi (D0TB01329C-(cit26)/*[position()=1]) 2004; 14
Dai (D0TB01329C-(cit7f)/*[position()=1]) 2018; 6
Reichardt (D0TB01329C-(cit15)/*[position()=1]) 2002
Gleiter (D0TB01329C-(cit20)/*[position()=1]) 2018; 118
Hou (D0TB01329C-(cit22d)/*[position()=1]) 2018; 90
Oddershede (D0TB01329C-(cit25)/*[position()=1]) 2003; 1
Cai (D0TB01329C-(cit11b)/*[position()=1]) 2020; 18
Chen (D0TB01329C-(cit22a)/*[position()=1]) 2019; 55
Luby-Phelps (D0TB01329C-(cit1c)/*[position()=1]) 1999
Huang (D0TB01329C-(cit21b)/*[position()=1]) 2011; 47
Xie (D0TB01329C-(cit10a)/*[position()=1]) 2016; 88
Han (D0TB01329C-(cit10b)/*[position()=1]) 2015; 7
Futerman (D0TB01329C-(cit5a)/*[position()=1]) 2004; 5
Jiang (D0TB01329C-(cit7d)/*[position()=1]) 2014; 190
Liu (D0TB01329C-(cit14c)/*[position()=1]) 2017; 53
References_xml – issn: 2002
  publication-title: Solvents and Solvent Effects in Organic Chemis-try
  doi: Reichardt
– issn: 1999
  end-page: 189
  publication-title: Int. Rev. Cytol.
  doi: Luby-Phelps
– volume: 49
  start-page: 2115
  year: 2016
  ident: D0TB01329C-(cit6b)/*[position()=1]
  publication-title: Acc. Chem. Res.
  doi: 10.1021/acs.accounts.6b00292
– volume: 7
  start-page: 3569
  year: 2019
  ident: D0TB01329C-(cit14b)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C8TB03353F
– volume: 190
  start-page: 685
  year: 2014
  ident: D0TB01329C-(cit7d)/*[position()=1]
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2013.09.062
– volume: 309
  start-page: 127764
  year: 2020
  ident: D0TB01329C-(cit23a)/*[position()=1]
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2020.127764
– volume: 50
  start-page: 1410
  year: 2017
  ident: D0TB01329C-(cit9d)/*[position()=1]
  publication-title: Acc. Chem. Res.
  doi: 10.1021/acs.accounts.7b00087
– volume: 55
  start-page: 3469
  year: 2019
  ident: D0TB01329C-(cit12a)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C9CC01068H
– volume: 24
  start-page: 2593
  year: 2013
  ident: D0TB01329C-(cit1d)/*[position()=1]
  publication-title: Mol. Biol. Cell.
  doi: 10.1091/mbc.e12-08-0617
– volume: 149
  start-page: 253
  year: 2018
  ident: D0TB01329C-(cit8b)/*[position()=1]
  publication-title: Dyes Pigm.
  doi: 10.1016/j.dyepig.2017.10.002
– volume: 14
  start-page: 1265
  year: 2000
  ident: D0TB01329C-(cit22c)/*[position()=1]
  publication-title: FASEB J.
– volume: 20
  start-page: 159
  year: 2002
  ident: D0TB01329C-(cit2a)/*[position()=1]
  publication-title: J. Hypertens.
  doi: 10.1097/00004872-200202000-00001
– volume: 7
  start-page: 27968
  year: 2015
  ident: D0TB01329C-(cit10b)/*[position()=1]
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.5b10607
– volume: 271
  start-page: 321
  year: 2018
  ident: D0TB01329C-(cit7b)/*[position()=1]
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2018.05.055
– volume: 49
  start-page: 2445
  year: 2013
  ident: D0TB01329C-(cit19)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/c3cc39269d
– volume: 46
  start-page: 7105
  year: 2017
  ident: D0TB01329C-(cit6c)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/C7CS00240H
– volume: 88
  start-page: 8019
  year: 2016
  ident: D0TB01329C-(cit10a)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.6b01256
– volume: 53
  start-page: 10727
  year: 2017
  ident: D0TB01329C-(cit14c)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C7CC06220F
– volume: 14
  start-page: 359
  year: 1995
  ident: D0TB01329C-(cit24)/*[position()=1]
  publication-title: Gen. Physiol. Biophys.
– volume: 10
  start-page: 459
  year: 2000
  ident: D0TB01329C-(cit5c)/*[position()=1]
  publication-title: Trends Cell Biol.
  doi: 10.1016/S0962-8924(00)01847-X
– volume: 8
  start-page: 622
  year: 2007
  ident: D0TB01329C-(cit3b)/*[position()=1]
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2217
– volume: 16
  start-page: 7163
  year: 2018
  ident: D0TB01329C-(cit14d)/*[position()=1]
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/C8OB01701H
– volume: 90
  start-page: 5873
  year: 2018
  ident: D0TB01329C-(cit17)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.8b00590
– volume: 15
  start-page: 3947
  year: 2017
  ident: D0TB01329C-(cit6a)/*[position()=1]
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/C7OB00538E
– volume: 285
  start-page: 156
  year: 2019
  ident: D0TB01329C-(cit14a)/*[position()=1]
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2019.01.045
– volume: 8
  start-page: 2269
  year: 2020
  ident: D0TB01329C-(cit11a)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C9TB02609F
– volume: 304
  start-page: 127271
  year: 2020
  ident: D0TB01329C-(cit7g)/*[position()=1]
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2019.127271
– volume: 3
  start-page: 2416
  year: 2018
  ident: D0TB01329C-(cit13a)/*[position()=1]
  publication-title: ChemistrySelect
  doi: 10.1002/slct.201703131
– volume: 160
  start-page: 989
  year: 2019
  ident: D0TB01329C-(cit14e)/*[position()=1]
  publication-title: Dyes Pigm.
  doi: 10.1016/j.dyepig.2018.07.001
– volume: 55
  start-page: 5060
  year: 2019
  ident: D0TB01329C-(cit22a)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C9CC01263J
– volume: 4
  start-page: 7363
  year: 2016
  ident: D0TB01329C-(cit22b)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C6TB02463G
– volume: 6
  start-page: 381
  year: 2018
  ident: D0TB01329C-(cit7f)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB02414B
– volume: 203
  start-page: 127
  year: 2018
  ident: D0TB01329C-(cit7l)/*[position()=1]
  publication-title: Spectrochim. Acta, Part A
  doi: 10.1016/j.saa.2018.05.121
– volume: 118
  start-page: 2010
  year: 2018
  ident: D0TB01329C-(cit20)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.7b00449
– volume: 128
  start-page: 398
  year: 2006
  ident: D0TB01329C-(cit7a)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja056370a
– volume: 90
  start-page: 7122
  year: 2018
  ident: D0TB01329C-(cit22d)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.8b01631
– volume: 6
  start-page: 580
  year: 2018
  ident: D0TB01329C-(cit7h)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB02615C
– volume: 59
  start-page: 4540
  year: 2018
  ident: D0TB01329C-(cit7o)/*[position()=1]
  publication-title: Tetrahedron Lett.
  doi: 10.1016/j.tetlet.2018.11.009
– volume: 91
  start-page: 11409
  year: 2019
  ident: D0TB01329C-(cit10c)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.9b02782
– volume: 43
  start-page: 4563
  year: 2014
  ident: D0TB01329C-(cit1b)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/C4CS00051J
– volume: 41
  start-page: 1947
  year: 2012
  ident: D0TB01329C-(cit1a)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/C1CS15168A
– volume: 125
  start-page: 89
  year: 2016
  ident: D0TB01329C-(cit7n)/*[position()=1]
  publication-title: Dyes Pigm.
  doi: 10.1016/j.dyepig.2015.10.012
– volume: 53
  start-page: 5886
  year: 2017
  ident: D0TB01329C-(cit12b)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C7CC03417B
– volume: 135
  start-page: 9181
  year: 2013
  ident: D0TB01329C-(cit2c)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja403851p
– volume: 135
  start-page: 2903
  year: 2013
  ident: D0TB01329C-(cit4b)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja311688g
– volume: 130
  start-page: 66723
  year: 2008
  ident: D0TB01329C-(cit5b)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja800570d
– volume: 1
  start-page: 1053
  year: 2003
  ident: D0TB01329C-(cit25)/*[position()=1]
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/b211130f
– volume: 5
  start-page: 554
  year: 2004
  ident: D0TB01329C-(cit5a)/*[position()=1]
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1423
– volume: 4
  start-page: 5418
  year: 2015
  ident: D0TB01329C-(cit4a)/*[position()=1]
  publication-title: Sci. Rep.
  doi: 10.1038/srep05418
– volume-title: Solvents and Solvent Effects in Organic Chemis-try
  year: 2002
  ident: D0TB01329C-(cit15)/*[position()=1]
  doi: 10.1002/3527601791
– volume: 5
  start-page: 886
  year: 2005
  ident: D0TB01329C-(cit18)/*[position()=1]
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1738
– volume: 158
  start-page: 105191
  year: 2020
  ident: D0TB01329C-(cit1e)/*[position()=1]
  publication-title: Microchem. J.
  doi: 10.1016/j.microc.2020.105191
– volume: 24
  start-page: 10999
  year: 2018
  ident: D0TB01329C-(cit13b)/*[position()=1]
  publication-title: Chem. – Eur. J.
  doi: 10.1002/chem.201801918
– volume: 168
  start-page: 134
  year: 2019
  ident: D0TB01329C-(cit7c)/*[position()=1]
  publication-title: Dyes Pigm.
  doi: 10.1016/j.dyepig.2019.04.049
– volume: 9
  start-page: 2606
  year: 2011
  ident: D0TB01329C-(cit21a)/*[position()=1]
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/c0ob01060j
– start-page: 189
  volume-title: Int. Rev. Cytol.
  year: 1999
  ident: D0TB01329C-(cit1c)/*[position()=1]
– volume: 138
  start-page: 12368
  year: 2016
  ident: D0TB01329C-(cit23b)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b04048
– volume: 96
  start-page: 424
  year: 2013
  ident: D0TB01329C-(cit21c)/*[position()=1]
  publication-title: Dyes Pigm.
  doi: 10.1016/j.dyepig.2012.09.010
– volume: 55
  start-page: 14728
  year: 2016
  ident: D0TB01329C-(cit9b)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201609895
– volume: 90
  start-page: 7122
  year: 2018
  ident: D0TB01329C-(cit7j)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.8b01631
– volume: 91
  start-page: 10302
  year: 2019
  ident: D0TB01329C-(cit7k)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.9b02678
– volume: 55
  start-page: 2688
  year: 2019
  ident: D0TB01329C-(cit7i)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C9CC00113A
– volume: 171
  start-page: 107709
  year: 2019
  ident: D0TB01329C-(cit6d)/*[position()=1]
  publication-title: Dyes Pigm.
  doi: 10.1016/j.dyepig.2019.107709
– volume: 7
  start-page: 2749
  year: 2019
  ident: D0TB01329C-(cit8a)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C9TB00043G
– volume: 293
  start-page: 1485
  year: 2002
  ident: D0TB01329C-(cit2b)/*[position()=1]
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/S0006-291X(02)00422-9
– volume: 18
  start-page: 1148
  year: 2020
  ident: D0TB01329C-(cit11b)/*[position()=1]
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/C9OB02188D
– volume: 91
  start-page: 8415
  year: 2019
  ident: D0TB01329C-(cit7m)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.9b01293
– volume: 55
  start-page: 155
  year: 2016
  ident: D0TB01329C-(cit9a)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201507031
– volume: 14
  start-page: 465
  year: 2004
  ident: D0TB01329C-(cit26)/*[position()=1]
  publication-title: J. Fluoresc.
  doi: 10.1023/B:JOFL.0000031828.96368.c1
– volume: 136
  start-page: 4697
  year: 2014
  ident: D0TB01329C-(cit9c)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja500315x
– volume: 47
  start-page: 2408
  year: 2011
  ident: D0TB01329C-(cit21b)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C0CC04589F
– volume: 75
  start-page: 63
  year: 1971
  ident: D0TB01329C-(cit16)/*[position()=1]
  publication-title: Z. Phys. Chem.
  doi: 10.1524/zpch.1971.75.1_2.063
– volume: 10
  start-page: 623
  year: 2009
  ident: D0TB01329C-(cit3a)/*[position()=1]
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2745
– volume: 277
  start-page: 55
  year: 2018
  ident: D0TB01329C-(cit7e)/*[position()=1]
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2018.08.109
SSID ssj0000816834
Score 2.4071953
Snippet The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g. ,...
The viscosity of lysosomes plays a significant role in modulating biological processes and reflects the status and function of this kind of organelle, e.g.,...
SourceID proquest
pubmed
crossref
rsc
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 8838
SubjectTerms Biological activity
Biomonitoring
Cells (biology)
Confocal microscopy
Fluorescence
fluorescent dyes
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent indicators
Glycerol
HeLa Cells
Humans
I.R. radiation
indoles
Indoles - chemical synthesis
Indoles - chemistry
Lysosomes
Lysosomes - chemistry
Lysosomes - metabolism
Microscopy, Confocal - methods
Microscopy, Fluorescence - methods
Morphology
near infrared radiation
Organoselenium Compounds - chemical synthesis
Organoselenium Compounds - chemistry
Temporal resolution
Viscosity
Xanthene
xanthenes
Xanthenes - chemical synthesis
Xanthenes - chemistry
Title A lysosome-targeting viscosity-sensitive fluorescent probe based on a novel functionalised near-infrared xanthene-indolium dye and its application in living cells
URI https://www.ncbi.nlm.nih.gov/pubmed/33026403
https://www.proquest.com/docview/2448843261
https://www.proquest.com/docview/2449182075
https://www.proquest.com/docview/2985670895
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbK9gIPiNugYyAjeEFRhttcmjx2Y6igwlOQ9hYljjMiZcnUNBPl5_D3-BOcYzuXLgUNXqLEdqLE58u5-5iQN9Zs5qWTSJgxWBemHcepGSWWb04TwWKWgoxNcaHw5y_u4qv96dw5H41-9bKW6nV8zH_sXFfyP1SFNqArrpL9B8q2D4UGOAf6whEoDMdb0Xhu5JuqrMpLYaqMbrT7r7OKYybWxqwwOV3V9c7rcqUKN2FGViwMlF4JRgoioyivRW6ggFN-wQx7CvgDTHjHlUxQ_w7z_w24IrQkZZ7Vl0ay6eIOvSA4uk_yTDopMCRQ_UH3BTVZzY_Bmw3njo0TtXao6ZF5pL0SUTezAJZZrfMFtPBV7m_p-g3Krm2hnOzlcNQSHTrwWRd91wfYuRi4n3UccsocZoLKc66EWb9NM3XN4r0eklUxGc2vPU9fatnvqWKUA7nCLCzL-p4FJxib8k876dlkDNwQqm2qowzyW37Y3XuH7E_BpgGmvD8_Cz4uW5eg3ANF5kG0H9YU1LX8d90DtlWogV0EWtKq2b1GaknBA3Jfk5jOFVYfkpEoHpF7vaKXj8nPOR2ilu5ALe2hlkrUUolaWhY0ohK1dBu1dAu1dIBaCqilgCUKqKU91NKsoAq1VKL2CQk-nAWnC1PvFGJy252uTcFxiXbkJLaVcjiPuCcwIO-7kc-nqbAnKWPCZXDFsYKm7aRJAop_CuaB7fjWAdkrykI8I9RjfsTs2PVim4GlYEced3FtNijucWq5bEzeNnMfcl1FHzdzycMhocfkdTv2StWO2TnqqCFhqHlLFYLSDVgE02oyJq_abvgfcRaiQpS1HOPj9gsz5y9jfM9xZ8zzYcxTBY_2VSyYIddm1pgcAF7a5oStY_lmfEwOd3eEV0l6eKuPe07udj_uEdlbr2rxArT4dfxSo_83WN75qA
linkProvider Royal Society of Chemistry
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+lysosome-targeting+viscosity-sensitive+fluorescent+probe+based+on+a+novel+functionalised+near-infrared+xanthene-indolium+dye+and+its+application+in+living+cells&rft.jtitle=Journal+of+materials+chemistry.+B%2C+Materials+for+biology+and+medicine&rft.au=Liu%2C+Chang&rft.au=Zhao%2C+Tong&rft.au=He%2C+Song&rft.au=Zhao%2C+Liancheng&rft.date=2020-10-07&rft.issn=2050-750X&rft.eissn=2050-7518&rft.volume=8&rft.issue=38&rft.spage=8838&rft.epage=8844&rft_id=info:doi/10.1039%2FD0TB01329C&rft.externalDBID=n%2Fa&rft.externalDocID=10_1039_D0TB01329C
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-750X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-750X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-750X&client=summon