Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response

• Published in: Frontiers in physiology Vol. 9; p. 618
• Main Authors: Bösl, Korbinian, Giambelluca, Miriam, Haug, Markus, Bugge, Marit, Espevik, Terje, Kandasamy, Richard K., Bergstrøm, Bjarte
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 29.05.2018
• Subjects: innate immunity; monocytes; Physiology; signaling; Toll-like receptor 2; Toll-like receptor 8; Toll-like receptors; Toll-like receptors; monocytes; signaling; Toll-like receptor 8; innate immunity; Toll-like receptor 2

Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated...