Coffee enhances the expression of chaperones and antioxidant proteins in rats with nonalcoholic fatty liver disease

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 163; no. 6; pp. 593 - 602
• Main Authors: Salomone, Federico, Li Volti, Giovanni, Vitaglione, Paola, Morisco, Filomena, Fogliano, Vincenzo, Zappalà, Agata, Palmigiano, Angelo, Garozzo, Domenico, Caporaso, Nicola, D’Argenio, Giuseppe, Galvano, Fabio
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.06.2014
• Subjects: Animals; Antioxidants - metabolism; Coffee; Diet, High-Fat - adverse effects; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Endoplasmic Reticulum - metabolism; Fatty Liver - diet therapy; Fatty Liver - genetics; Fatty Liver - metabolism; Gene Expression; Heat-Shock Proteins - biosynthesis; Heat-Shock Proteins - genetics; HSP70 Heat-Shock Proteins - genetics; HSP70 Heat-Shock Proteins - metabolism; Internal Medicine; Male; Mitochondria, Liver - metabolism; Molecular Chaperones - metabolism; Non-alcoholic Fatty Liver Disease; Protein Disulfide-Isomerases - genetics; Protein Disulfide-Isomerases - metabolism; Proteomics; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Translational Medical Research; FFA; mtHSP70; NAFLD; HSP70; PRDX1; HFD; ROS; ALT; PAGE; NASH; ER; PCR; alanine aminotransferase; peroxiredoxin 1; nonalcoholic steatohepatitis; nonalcoholic fatty liver disease; free fatty acid; high-fat diet; reactive oxygen species; heat shock protein 70; mitochondrial heat shock protein 70; polyacrylamide gel electrophoresis; endoplasmic reticulum; polymerase chain reaction
• ISSN: 1931-5244; 1878-1810; 1878-1810
• DOI: 10.1016/j.trsl.2013.12.001

Coffee consumption is inversely related to the degree of liver injury in patients with nonalcoholic fatty liver disease (NAFLD). Molecular mediators contributing to coffee’s beneficial effects in NAFLD remain to be elucidated. In this study, we administrated decaffeinated espresso coffee or vehicle...