Heparin binding epidermal growth factor-like growth factor is a prognostic marker correlated with levels of macrophages infiltrated in lung adenocarcinoma

• Published in: Frontiers in oncology Vol. 12; p. 963896
• Main Authors: Van Hiep, Nguyen, Sun, Wei-Lun, Feng, Po-Hao, Lin, Cheng-Wei, Chen, Kuan-Yuan, Luo, Ching-Shan, Dung, Le Ngoc, Van Quyet, Hoang, Wu, Sheng-Ming, Lee, Kang-Yun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.11.2022
• Subjects: bioinformatics; biomarker; heparin-binding EGF-like growth factor (HBEGF); immune infiltration; macrophage chemotaxis; non-small cell lung cancer; Oncology; non-small cell lung cancer; macrophage chemotaxis; immune infiltration; biomarker; heparin-binding EGF-like growth factor (HBEGF); bioinformatics

The interactions between tumor cells and the host immune system play a crucial role in lung cancer progression and resistance to treatment. The alterations of EGFR signaling have the potential to produce an ineffective tumor-associated immune microenvironment by upregulating a series of immune suppr...